FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031189496> ?p ?o ?g. }

• W2031189496 endingPage "2931" @default.
• W2031189496 startingPage "2925" @default.
• W2031189496 abstract "Class switch recombination (CSR) is mediated by G-rich tandem repeated sequences termed switch regions. Transcription of switch regions generates single-stranded R loops that provide substrates for activation-induced cytidine deaminase. Mice deficient in MSH2 have a mild defect in CSR and analysis of their switch junctions has led to a model in which MSH2 is more critical for switch recombination events outside than within the tandem repeats. It is also known that deletion of the whole Sμ region severely impairs but does not abrogate CSR despite the lack of detectable R loops. Here, we demonstrate that deficiency of both MSH2 and the Sμ region completely abolishes CSR and that the abrogation occurs at the genomic level. This finding further supports the crucial role of MSH2 outside the tandem repeats. It also indicates that during CSR, MSH2 has access to activation-induced cytidine deaminase targets in R-loop-deficient Iμ-Cμ sequences rarely used in CSR, suggesting an MSH2-dependent DNA processing activity at the Iμ exon that may decrease with transcription elongation across the Sμ region." @default.
• W2031189496 created "2016-06-24" @default.
• W2031189496 creator A5002663644 @default.
• W2031189496 creator A5047288855 @default.
• W2031189496 creator A5053547985 @default.
• W2031189496 creator A5071830926 @default.
• W2031189496 creator A5074351903 @default.
• W2031189496 date "2010-07-26" @default.
• W2031189496 modified "2023-10-18" @default.
• W2031189496 title "Combined deficiency of MSH2 and Sμ region abolishes class switch recombination" @default.
• W2031189496 cites W1504583071 @default.
• W2031189496 cites W1572555010 @default.
• W2031189496 cites W1967205646 @default.
• W2031189496 cites W1967913844 @default.
• W2031189496 cites W1968490259 @default.
• W2031189496 cites W1970966311 @default.
• W2031189496 cites W1972564604 @default.
• W2031189496 cites W1980628113 @default.
• W2031189496 cites W1980986854 @default.
• W2031189496 cites W1990060110 @default.
• W2031189496 cites W1993925602 @default.
• W2031189496 cites W2002043709 @default.
• W2031189496 cites W2007096393 @default.
• W2031189496 cites W2008383167 @default.
• W2031189496 cites W2013721615 @default.
• W2031189496 cites W2017472400 @default.
• W2031189496 cites W2024303560 @default.
• W2031189496 cites W2058806464 @default.
• W2031189496 cites W2059897736 @default.
• W2031189496 cites W2063488321 @default.
• W2031189496 cites W2080795138 @default.
• W2031189496 cites W2094094914 @default.
• W2031189496 cites W2098739051 @default.
• W2031189496 cites W2102296359 @default.
• W2031189496 cites W2113334835 @default.
• W2031189496 cites W2115981101 @default.
• W2031189496 cites W2116450256 @default.
• W2031189496 cites W2117421686 @default.
• W2031189496 cites W2132767317 @default.
• W2031189496 cites W2139664433 @default.
• W2031189496 cites W2141675922 @default.
• W2031189496 cites W2154841949 @default.
• W2031189496 cites W2160640824 @default.
• W2031189496 cites W2165608602 @default.
• W2031189496 doi "https://doi.org/10.1002/eji.201040605" @default.
• W2031189496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20812239" @default.
• W2031189496 hasPublicationYear "2010" @default.
• W2031189496 type Work @default.
• W2031189496 sameAs 2031189496 @default.
• W2031189496 citedByCount "1" @default.
• W2031189496 crossrefType "journal-article" @default.
• W2031189496 hasAuthorship W2031189496A5002663644 @default.
• W2031189496 hasAuthorship W2031189496A5047288855 @default.
• W2031189496 hasAuthorship W2031189496A5053547985 @default.
• W2031189496 hasAuthorship W2031189496A5071830926 @default.
• W2031189496 hasAuthorship W2031189496A5074351903 @default.
• W2031189496 hasConcept C104317684 @default.
• W2031189496 hasConcept C134935766 @default.
• W2031189496 hasConcept C137756551 @default.
• W2031189496 hasConcept C141231307 @default.
• W2031189496 hasConcept C153911025 @default.
• W2031189496 hasConcept C156695909 @default.
• W2031189496 hasConcept C159654299 @default.
• W2031189496 hasConcept C27082348 @default.
• W2031189496 hasConcept C27149982 @default.
• W2031189496 hasConcept C2776985229 @default.
• W2031189496 hasConcept C2778453870 @default.
• W2031189496 hasConcept C2779115348 @default.
• W2031189496 hasConcept C36823959 @default.
• W2031189496 hasConcept C54355233 @default.
• W2031189496 hasConcept C60748783 @default.
• W2031189496 hasConcept C86803240 @default.
• W2031189496 hasConcept C95444343 @default.
• W2031189496 hasConceptScore W2031189496C104317684 @default.
• W2031189496 hasConceptScore W2031189496C134935766 @default.
• W2031189496 hasConceptScore W2031189496C137756551 @default.
• W2031189496 hasConceptScore W2031189496C141231307 @default.
• W2031189496 hasConceptScore W2031189496C153911025 @default.
• W2031189496 hasConceptScore W2031189496C156695909 @default.
• W2031189496 hasConceptScore W2031189496C159654299 @default.
• W2031189496 hasConceptScore W2031189496C27082348 @default.
• W2031189496 hasConceptScore W2031189496C27149982 @default.
• W2031189496 hasConceptScore W2031189496C2776985229 @default.
• W2031189496 hasConceptScore W2031189496C2778453870 @default.
• W2031189496 hasConceptScore W2031189496C2779115348 @default.
• W2031189496 hasConceptScore W2031189496C36823959 @default.
• W2031189496 hasConceptScore W2031189496C54355233 @default.
• W2031189496 hasConceptScore W2031189496C60748783 @default.
• W2031189496 hasConceptScore W2031189496C86803240 @default.
• W2031189496 hasConceptScore W2031189496C95444343 @default.
• W2031189496 hasIssue "10" @default.
• W2031189496 hasLocation W20311894961 @default.
• W2031189496 hasLocation W20311894962 @default.
• W2031189496 hasOpenAccess W2031189496 @default.
• W2031189496 hasPrimaryLocation W20311894961 @default.
• W2031189496 hasRelatedWork W1909551469 @default.
• W2031189496 hasRelatedWork W1971010738 @default.
• W2031189496 hasRelatedWork W2031189496 @default.

• next