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- W2031193463 abstract "Capsules, containing the poly(acrylic acid) derivative Carbopol® 934P (C934P) with the aim of inhibiting intestinal proteolytic activities after swelling with water into a hydrated state, were designed. Erythrosin was used as a hydrophillic model drug to characterize the release properties of the dosage forms. Capsule formulations which rapidly disintegrated and released the drug quickly, were prepared because both rapid disintegration and rapid swelling of C934P and simultaneous drug release are prerequisites for the enzyme inactivating properties of the system. The capsules containing freeze-dried, neutralized C934P (FNaC934P) disintegrated quicker than the capsules containing C934P. Capsules which contained poly(glycerol ester of fatty acid) microparticles with FNaC934P released erythrosin quicker than capsules containing mixtures of FNaC934P, erythrosin and a disintegrant." @default.
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- W2031193463 date "1996-06-01" @default.
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- W2031193463 title "Novel peroral dosage forms with protease inhibitory activities. I. Design of capsules with fast gel-forming and fast drug-releasing properties" @default.
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- W2031193463 doi "https://doi.org/10.1016/0378-5173(95)04505-8" @default.
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