Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031194787> ?p ?o ?g. }
- W2031194787 endingPage "1360" @default.
- W2031194787 startingPage "1349" @default.
- W2031194787 abstract "Somatic symptoms experienced by women with a menstrually related mood disorder (MRMD) during their premenstrual luteal phase contribute to functional impairment. Yet, investigations on pathophysiological mechanisms contributing to heightened pain sensitivity in MRMD are sparse. During the luteal phase, 61 women with an MRMD and 61 non-MRMD controls were evaluated for β-adrenergic receptor (β-AR) responsivity using the isoproterenol sensitivity test. A subset (43 MRMD and 50 non-MRMD) then entered a double-blind, placebo-controlled, crossover protocol to examine the effect of β-AR blockade with intravenous propranolol on sensitivity to experimental (cold pressor and ischemic) and clinical (McGill Pain Questionnaire score) pain. Women with an MRMD exhibited greater β1- and β2-AR responsivity, ischemic pain intensity, and affective clinical pain ratings than controls. Propranolol increased cold pressor pain tolerance in both groups, but it decreased cold pain intensity and ischemic pain unpleasantness ratings only in non-MRMD women. In contrast, propranolol decreased affective ratings of clinical pain in women with MRMD. Exploratory analyses indicated that only in MRMD women did greater β-AR responsivity predict greater sensitivity to cold pressor and ischemic pain. This study provides the first evidence for a role of β-AR mechanisms in the hyperalgesia and clinical pain experienced by women with MRMDs. Perspective This article describes the effects of β-adrenergic receptor stimulation and blockade on experimental and clinical pain sensitivity in women with an MRMD. The results of this study may have implications for the management of the substantial somatic premenstrual symptomatology experienced by women with an MRMD." @default.
- W2031194787 created "2016-06-24" @default.
- W2031194787 creator A5021737959 @default.
- W2031194787 creator A5041608083 @default.
- W2031194787 creator A5048183042 @default.
- W2031194787 creator A5054398235 @default.
- W2031194787 creator A5059143302 @default.
- W2031194787 creator A5088870384 @default.
- W2031194787 date "2013-11-01" @default.
- W2031194787 modified "2023-09-30" @default.
- W2031194787 title "Beta-Adrenergic Receptor Mechanisms and Pain Sensitivity in Women With Menstrually Related Mood Disorders" @default.
- W2031194787 cites W1546925727 @default.
- W2031194787 cites W1892067259 @default.
- W2031194787 cites W1967171157 @default.
- W2031194787 cites W1969054157 @default.
- W2031194787 cites W1970114251 @default.
- W2031194787 cites W1970713121 @default.
- W2031194787 cites W1974681697 @default.
- W2031194787 cites W1984503612 @default.
- W2031194787 cites W1995898642 @default.
- W2031194787 cites W1997799083 @default.
- W2031194787 cites W1999975653 @default.
- W2031194787 cites W2000399989 @default.
- W2031194787 cites W2003230512 @default.
- W2031194787 cites W2004934852 @default.
- W2031194787 cites W2006520004 @default.
- W2031194787 cites W2015394973 @default.
- W2031194787 cites W2015682236 @default.
- W2031194787 cites W2016668868 @default.
- W2031194787 cites W2021774599 @default.
- W2031194787 cites W2022936592 @default.
- W2031194787 cites W2027714672 @default.
- W2031194787 cites W2030289876 @default.
- W2031194787 cites W2033595520 @default.
- W2031194787 cites W2033638599 @default.
- W2031194787 cites W2036041691 @default.
- W2031194787 cites W2039380252 @default.
- W2031194787 cites W2040493240 @default.
- W2031194787 cites W2041726586 @default.
- W2031194787 cites W2043250884 @default.
- W2031194787 cites W2046110224 @default.
- W2031194787 cites W2048489406 @default.
- W2031194787 cites W2048753457 @default.
- W2031194787 cites W2059633569 @default.
- W2031194787 cites W2067479353 @default.
- W2031194787 cites W2068467370 @default.
- W2031194787 cites W2071564105 @default.
- W2031194787 cites W2071837229 @default.
- W2031194787 cites W2072875422 @default.
- W2031194787 cites W2073659954 @default.
- W2031194787 cites W2073793769 @default.
- W2031194787 cites W2074290145 @default.
- W2031194787 cites W2074513082 @default.
- W2031194787 cites W2075209490 @default.
- W2031194787 cites W2080063973 @default.
- W2031194787 cites W2081776574 @default.
- W2031194787 cites W2083737567 @default.
- W2031194787 cites W2085511080 @default.
- W2031194787 cites W2085625476 @default.
- W2031194787 cites W2088013883 @default.
- W2031194787 cites W2095116865 @default.
- W2031194787 cites W2097674540 @default.
- W2031194787 cites W2134814434 @default.
- W2031194787 cites W2138407894 @default.
- W2031194787 cites W2141764590 @default.
- W2031194787 cites W2144961120 @default.
- W2031194787 cites W2145738275 @default.
- W2031194787 cites W2146481987 @default.
- W2031194787 cites W2168523030 @default.
- W2031194787 cites W2171230014 @default.
- W2031194787 cites W2172060077 @default.
- W2031194787 cites W2326830786 @default.
- W2031194787 cites W2334180745 @default.
- W2031194787 doi "https://doi.org/10.1016/j.jpain.2013.05.014" @default.
- W2031194787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23958279" @default.
- W2031194787 hasPublicationYear "2013" @default.
- W2031194787 type Work @default.
- W2031194787 sameAs 2031194787 @default.
- W2031194787 citedByCount "3" @default.
- W2031194787 countsByYear W20311947872014 @default.
- W2031194787 countsByYear W20311947872018 @default.
- W2031194787 countsByYear W20311947872021 @default.
- W2031194787 crossrefType "journal-article" @default.
- W2031194787 hasAuthorship W2031194787A5021737959 @default.
- W2031194787 hasAuthorship W2031194787A5041608083 @default.
- W2031194787 hasAuthorship W2031194787A5048183042 @default.
- W2031194787 hasAuthorship W2031194787A5054398235 @default.
- W2031194787 hasAuthorship W2031194787A5059143302 @default.
- W2031194787 hasAuthorship W2031194787A5088870384 @default.
- W2031194787 hasBestOaLocation W20311947871 @default.
- W2031194787 hasConcept C118552586 @default.
- W2031194787 hasConcept C126322002 @default.
- W2031194787 hasConcept C14184104 @default.
- W2031194787 hasConcept C142724271 @default.
- W2031194787 hasConcept C204787440 @default.
- W2031194787 hasConcept C27081682 @default.
- W2031194787 hasConcept C2776432500 @default.
- W2031194787 hasConcept C2777547206 @default.