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- W2031204144 abstract "The nucleoprotein structure of the mouse mammary tumor virus (MMTV) promoter defines its response to cAMP signaling. A stably replicating MMTV template in highly organized chromatin is repressed in the presence of cAMP, whereas a transiently transfected template with a disorganized structure is activated. In this study, we investigate the nature of the cAMP-induced signal(s) by which these opposing responses occur to gain insight into their mechanism. We demonstrate that the transcriptional changes observed at both templates are mediated through cAMP-dependent protein kinase A (PKA). In addition, the MMTV promoter lacks a consensus cAMP response element (CRE) and neither template requires cAMP response element-binding protein (CREB) to elicit a response to cAMP signaling. However, the responses of the two templates differ mechanistically in that the CREB-binding protein p300 potentiates activation from the transient template in a manner dependent on its Cys/His-rich region 3, but does not appear to affect the repression of the replicating chromatin template. Chromatin immunoprecipitation assays show that cAMP treatment results in a decrease in acetylation of histone H4, and in multiple modifications of histone H3 at specific nucleosomes in the promoter region of the stable MMTV template. These findings suggest novel CREB-independent, chromatin-dependent pathways for transcriptional regulation by cAMP." @default.
- W2031204144 created "2016-06-24" @default.
- W2031204144 creator A5001132124 @default.
- W2031204144 creator A5010327270 @default.
- W2031204144 creator A5019693222 @default.
- W2031204144 creator A5049834786 @default.
- W2031204144 date "2003-07-15" @default.
- W2031204144 modified "2023-10-18" @default.
- W2031204144 title "Chromatin-dependent regulation of the MMTV promoter by cAMP signaling is mediated through distinct pathways" @default.
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- W2031204144 doi "https://doi.org/10.1016/s0014-4827(03)00153-8" @default.
- W2031204144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12837291" @default.
- W2031204144 hasPublicationYear "2003" @default.
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