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- W2031207947 abstract "Bcl-2 proteins are acknowledged as key regulators of programmed cell death. However, increasing data suggest additional roles, including regulation of the cell cycle, metabolism and cytoskeletal dynamics. Here we report the discovery and characterization of a new Bcl-2-related multidomain apoptosis accelerator, Bcl-wav, found in fish and frogs. Genetic and molecular studies in zebrafish indicate that Bcl-wav and the recently identified mitochondrial calcium uniporter (MCU) contribute to the formation of the notochord axis by controlling blastomere convergence and extension movements during gastrulation. Furthermore, we found that Bcl-wav controls intracellular Ca(2+) trafficking by acting on the mitochondrial voltage-dependent anion channel, and possibly on MCU, with direct consequences on actin microfilament dynamics and blastomere migration guidance. Thus, from an evolutionary point of view, the original function of Bcl-2 proteins might have been to contribute in controlling the global positioning system of blastomeres during gastrulation, a critical step in metazoan development." @default.
- W2031207947 created "2016-06-24" @default.
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- W2031207947 date "2013-08-14" @default.
- W2031207947 modified "2023-10-18" @default.
- W2031207947 title "Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish" @default.
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- W2031207947 doi "https://doi.org/10.1038/ncomms3330" @default.
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