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• W2031230908 abstract "LFB1/HNF1 is a hepatocyte-enriched frans-activator involved in the regulation of many liver-specific genes. We report the cloning and characterization of a rat genomic DNA fragment containing about 3.5 kb of the LFB1/HNF1 gene 5′-flanking region. This DNA segment is capable of directing the liver-specific expression of a reporter gene in transfection assays. More interestingly, the basal activity of the LFB1/HNF1 promoter in cultured hepatoma cell lines is downregulated by exogenously added LFB1/HNF1 protein itself. The ability to repress transcription starting from its own promoter requires the integrity of the N-terminal LFB1/HNF1 DNA-binding domain. Contrary to the expectations, in vitro binding experiments failed to demonstrate any specific and functional interaction of purified LFB1/HNF1 with the -3.5 kb promoter sequence. In addition to the DNA-binding domain, a 60 aa region contained in the C-terminus of the protein and distinct from the previously characterized activation domains, is also required for the repressing function." @default.
• W2031230908 created "2016-06-24" @default.
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• W2031230908 date "1994-01-01" @default.
• W2031230908 modified "2023-10-16" @default.
• W2031230908 title "LFB1/HNF1 acts as a repressor of its own transcription" @default.
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• W2031230908 doi "https://doi.org/10.1093/nar/22.20.4284" @default.
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• W2031230908 hasPublicationYear "1994" @default.
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