Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031255342> ?p ?o ?g. }
- W2031255342 endingPage "85" @default.
- W2031255342 startingPage "72" @default.
- W2031255342 abstract "The molecular mechanisms of mechanotransduction in regulating mesenchymal stem cell (MSC) chondrogenesis are not fully understood and represent an area of growing investigation. In this study, human MSC was subjected to chondrogenic differentiation in chitosan-coated poly l-lactide-co-ɛ-caprolactone scaffolds under free swelling or deferral dynamic compression conditions. The effect of deferral dynamic compression to MSC chondrogenesis and late stage hypertrophy development was investigated, and the involvement of TGF-β/SMAD pathway and integrin β1 signaling was analyzed. Deferral dynamic compression enhanced cartilage formation and suppressed chondrocyte hypertrophy. Differential cell morphology and cytoskeletal organization were induced under dynamic compression, together with the activation of TGF-β/Activin/Nodal and suppression of the BMP/GDP signaling. This was accompanied by the repression of integrin/FAK/ERK signaling in the non-hypertrophic cells when compared to the free swelling samples. Inhibition studies blocking TGF-β/Activin/Nodal signaling heightened hypertrophy, activate BMP/SMAD1/5/8 and integrin signaling, while inhibition of integrin-ECM interaction suppressed hypertrophy and activate TGF-β/SMAD2/3 in the free-swelling samples. This study demonstrates the roles of TGF-β/SMAD and integrin signaling, and suggests cross-talk between these two signaling pathways, in regulating the compression-driven hypertrophy development." @default.
- W2031255342 created "2016-06-24" @default.
- W2031255342 creator A5006285787 @default.
- W2031255342 creator A5009014905 @default.
- W2031255342 creator A5021485899 @default.
- W2031255342 creator A5022630581 @default.
- W2031255342 creator A5026115483 @default.
- W2031255342 creator A5029372692 @default.
- W2031255342 creator A5054426924 @default.
- W2031255342 creator A5082327048 @default.
- W2031255342 date "2015-01-01" @default.
- W2031255342 modified "2023-10-12" @default.
- W2031255342 title "Cross-talk between TGF-beta/SMAD and integrin signaling pathways in regulating hypertrophy of mesenchymal stem cell chondrogenesis under deferral dynamic compression" @default.
- W2031255342 cites W1528120845 @default.
- W2031255342 cites W1576773659 @default.
- W2031255342 cites W1603728190 @default.
- W2031255342 cites W1636022999 @default.
- W2031255342 cites W1968344552 @default.
- W2031255342 cites W1968746947 @default.
- W2031255342 cites W1973265846 @default.
- W2031255342 cites W197462632 @default.
- W2031255342 cites W1975417202 @default.
- W2031255342 cites W1988291232 @default.
- W2031255342 cites W1989959192 @default.
- W2031255342 cites W1993922152 @default.
- W2031255342 cites W2000335115 @default.
- W2031255342 cites W2011287092 @default.
- W2031255342 cites W2014940639 @default.
- W2031255342 cites W2015423555 @default.
- W2031255342 cites W2019730808 @default.
- W2031255342 cites W2020993672 @default.
- W2031255342 cites W2022721848 @default.
- W2031255342 cites W2025515198 @default.
- W2031255342 cites W2027600661 @default.
- W2031255342 cites W2032393093 @default.
- W2031255342 cites W2039065161 @default.
- W2031255342 cites W2040155058 @default.
- W2031255342 cites W2050273631 @default.
- W2031255342 cites W2052121307 @default.
- W2031255342 cites W2054053051 @default.
- W2031255342 cites W2054715164 @default.
- W2031255342 cites W2058774857 @default.
- W2031255342 cites W2067716147 @default.
- W2031255342 cites W2067767769 @default.
- W2031255342 cites W2072620529 @default.
- W2031255342 cites W2074800593 @default.
- W2031255342 cites W2076318547 @default.
- W2031255342 cites W2079846012 @default.
- W2031255342 cites W2084520414 @default.
- W2031255342 cites W2086318913 @default.
- W2031255342 cites W2087370958 @default.
- W2031255342 cites W2094567382 @default.
- W2031255342 cites W2094669780 @default.
- W2031255342 cites W2105183595 @default.
- W2031255342 cites W2108725095 @default.
- W2031255342 cites W2117814548 @default.
- W2031255342 cites W2118538079 @default.
- W2031255342 cites W2122883560 @default.
- W2031255342 cites W2126997734 @default.
- W2031255342 cites W2130837546 @default.
- W2031255342 cites W2135166914 @default.
- W2031255342 cites W2139205623 @default.
- W2031255342 cites W2140077756 @default.
- W2031255342 cites W2144250165 @default.
- W2031255342 cites W2146857985 @default.
- W2031255342 cites W2149208570 @default.
- W2031255342 cites W2155254610 @default.
- W2031255342 cites W2168419545 @default.
- W2031255342 cites W4213141530 @default.
- W2031255342 cites W4246921342 @default.
- W2031255342 cites W4251025034 @default.
- W2031255342 cites W4375923432 @default.
- W2031255342 cites W608456620 @default.
- W2031255342 doi "https://doi.org/10.1016/j.biomaterials.2014.10.010" @default.
- W2031255342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25453975" @default.
- W2031255342 hasPublicationYear "2015" @default.
- W2031255342 type Work @default.
- W2031255342 sameAs 2031255342 @default.
- W2031255342 citedByCount "93" @default.
- W2031255342 countsByYear W20312553422015 @default.
- W2031255342 countsByYear W20312553422016 @default.
- W2031255342 countsByYear W20312553422017 @default.
- W2031255342 countsByYear W20312553422018 @default.
- W2031255342 countsByYear W20312553422019 @default.
- W2031255342 countsByYear W20312553422020 @default.
- W2031255342 countsByYear W20312553422021 @default.
- W2031255342 countsByYear W20312553422022 @default.
- W2031255342 countsByYear W20312553422023 @default.
- W2031255342 crossrefType "journal-article" @default.
- W2031255342 hasAuthorship W2031255342A5006285787 @default.
- W2031255342 hasAuthorship W2031255342A5009014905 @default.
- W2031255342 hasAuthorship W2031255342A5021485899 @default.
- W2031255342 hasAuthorship W2031255342A5022630581 @default.
- W2031255342 hasAuthorship W2031255342A5026115483 @default.
- W2031255342 hasAuthorship W2031255342A5029372692 @default.
- W2031255342 hasAuthorship W2031255342A5054426924 @default.
- W2031255342 hasAuthorship W2031255342A5082327048 @default.
- W2031255342 hasConcept C134018914 @default.