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- W2031262928 endingPage "12895" @default.
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- W2031262928 abstract "Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis. Two pyrrole-imidazole polyamides were designed to bind DNA sequences immediately adjacent to binding sites for the transcription factors Ets-1, lymphoid-enhancer binding factor 1, and TATA-box binding protein. These synthetic ligands specifically inhibit DNA-binding of each transcription factor and HIV type 1 transcription in cell-free assays. When used in combination, the polyamides inhibit virus replication by >99% in isolated human peripheral blood lymphocytes, with no detectable cell toxicity. The ability of small molecules to target predetermined DNA sequences located within RNA polymerase II promoters suggests a general approach for regulation of gene expression, as well as a mechanism for the inhibition of viral replication." @default.
- W2031262928 created "2016-06-24" @default.
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- W2031262928 date "1998-10-27" @default.
- W2031262928 modified "2023-10-16" @default.
- W2031262928 title "Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands" @default.
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- W2031262928 doi "https://doi.org/10.1073/pnas.95.22.12890" @default.
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