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- W2031264199 abstract "Fluorescence imaging was used to determine the spatial and temporal patterns of subcellular calcium (Ca2+) liberation induced in Xenopus oocytes by photorelease of inositol 1,4,5-trisphosphate (InsP3) from a caged precursor. Increasing levels of InsP3 evoked Ca2+ release that began in a graded m anner but, at varying threshold levels of Ins-P3, localized sites then showed transient and asynchronous ‘puffs’ of Ca2+ release. With higher levels of Ins.P3, Ca2+ from adjacent sites formed a focus for initiation of a propagating Ca2+ wave. The results show that Ins.P3-sensitive Ca2+ stores are arranged as distinct and functionally independent units, and that Ca2+ is released in both graded and regenerative fashions." @default.
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- W2031264199 title "Regenerative release of calcium from functionally discrete subcellular stores by inositol trisphosphate" @default.
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