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• W2031283184 abstract "Significance A long-standing question in pheromone biosynthesis is the origin of the mevalonate pathway-derived precursor to frontalin, a key pheromone to the successful mass attack of conifer hosts by Dendroctonus bark beetles. Using a combination of genome and transcriptome analysis, functional characterization of expressed proteins, RNA interference, and transcript and metabolite analysis, we provide evidence that frontalin in the mountain pine beetle ( Dendroctonus ponderosae Hopkins) originates from the 20-carbon geranylgeranyl diphosphate rather than from 10-carbon geranyl diphosphate or 15-carbon farnesyl diphosphate. This result opens the way to study the later steps in frontalin biosynthesis." @default.
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• W2031283184 date "2013-10-28" @default.
• W2031283184 modified "2023-10-16" @default.
• W2031283184 title "Frontalin pheromone biosynthesis in the mountain pine beetle, <i>Dendroctonus ponderosae</i> , and the role of isoprenyl diphosphate synthases" @default.
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• W2031283184 doi "https://doi.org/10.1073/pnas.1316498110" @default.
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