Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031284310> ?p ?o ?g. }
- W2031284310 endingPage "150" @default.
- W2031284310 startingPage "131" @default.
- W2031284310 abstract "Colorectal cancer (CRC) ranks among the three most common cancers in terms of both cancer incidence and cancer-related deaths in most Western countries. Serrated adenocarcinoma is a recently described, distinct variant of CRC, accounting for about 7.5% of all CRCs and up to 17.5% of most proximal CRCs. It has been postulated that about 10-15% of sporadic CRCs would have their origin in serrated polyps that harbour a significant malignant potential. These lesions include hyperplastic-type aberrant crypt foci, hyperplastic polyps, sessile serrated adenomas, admixed polyps and serrated adenomas, and constitute the so-called 'serrated pathway', which is distinct from both the conventional adenoma-carcinoma pathway and the mutator pathway of hereditary non-polyposis CRC and is characterized by early involvement of oncogenic BRAF mutations, excess CpG island methylation (CIM) and subsequent low- or high-level DNA microsatellite instability (MSI). Methylation of hMLH1 is likely to explain the increased frequency of high-level MSI (16%) and methylation of MGMT is postulated to explain the low-level MSI (29%) in serrated adenocarcinomas. Reproducible histopathological criteria for serrated adenocarcinoma have recently been established and they have been qualified by DNA expression analysis for 7928 genes, showing clustering of serrated adenocarcinomas into a molecular entity apart from conventional adenocarcinoma, and representing with distinct down-regulation of EPHB2, PTCH and up-regulation of HIF1alpha." @default.
- W2031284310 created "2016-06-24" @default.
- W2031284310 creator A5046324591 @default.
- W2031284310 date "2007-01-01" @default.
- W2031284310 modified "2023-10-02" @default.
- W2031284310 title "Colorectal serrated adenocarcinoma" @default.
- W2031284310 cites W108969712 @default.
- W2031284310 cites W1526775146 @default.
- W2031284310 cites W1538930506 @default.
- W2031284310 cites W1723018635 @default.
- W2031284310 cites W1761586119 @default.
- W2031284310 cites W1877254421 @default.
- W2031284310 cites W1931116526 @default.
- W2031284310 cites W1963592300 @default.
- W2031284310 cites W1966997112 @default.
- W2031284310 cites W1969231537 @default.
- W2031284310 cites W1970064594 @default.
- W2031284310 cites W1971358842 @default.
- W2031284310 cites W1972558232 @default.
- W2031284310 cites W1972600888 @default.
- W2031284310 cites W1972998385 @default.
- W2031284310 cites W1975039405 @default.
- W2031284310 cites W1975895074 @default.
- W2031284310 cites W1977577913 @default.
- W2031284310 cites W1981298402 @default.
- W2031284310 cites W1983164217 @default.
- W2031284310 cites W1984662880 @default.
- W2031284310 cites W1985035689 @default.
- W2031284310 cites W1985184859 @default.
- W2031284310 cites W1986134198 @default.
- W2031284310 cites W1987229656 @default.
- W2031284310 cites W1993186240 @default.
- W2031284310 cites W1993883670 @default.
- W2031284310 cites W1995058700 @default.
- W2031284310 cites W1995081783 @default.
- W2031284310 cites W1995392458 @default.
- W2031284310 cites W1995819860 @default.
- W2031284310 cites W1996588062 @default.
- W2031284310 cites W1996998039 @default.
- W2031284310 cites W1997493715 @default.
- W2031284310 cites W1997665669 @default.
- W2031284310 cites W1998782720 @default.
- W2031284310 cites W1999104272 @default.
- W2031284310 cites W1999742139 @default.
- W2031284310 cites W2005831302 @default.
- W2031284310 cites W2007420407 @default.
- W2031284310 cites W2009476720 @default.
- W2031284310 cites W2010868528 @default.
- W2031284310 cites W2014906690 @default.
- W2031284310 cites W2015199877 @default.
- W2031284310 cites W2015363179 @default.
- W2031284310 cites W2015922200 @default.
- W2031284310 cites W2017256196 @default.
- W2031284310 cites W2018291992 @default.
- W2031284310 cites W2019354420 @default.
- W2031284310 cites W2019781712 @default.
- W2031284310 cites W2025927784 @default.
- W2031284310 cites W2028226155 @default.
- W2031284310 cites W2029105394 @default.
- W2031284310 cites W2029843689 @default.
- W2031284310 cites W2031037382 @default.
- W2031284310 cites W2031175489 @default.
- W2031284310 cites W2031526548 @default.
- W2031284310 cites W2032860211 @default.
- W2031284310 cites W2033689666 @default.
- W2031284310 cites W2034569398 @default.
- W2031284310 cites W2034888236 @default.
- W2031284310 cites W2036752083 @default.
- W2031284310 cites W2036873068 @default.
- W2031284310 cites W2037050524 @default.
- W2031284310 cites W2037201529 @default.
- W2031284310 cites W2037905074 @default.
- W2031284310 cites W2040257851 @default.
- W2031284310 cites W2042015284 @default.
- W2031284310 cites W2043150046 @default.
- W2031284310 cites W2043539979 @default.
- W2031284310 cites W2044643325 @default.
- W2031284310 cites W2044943025 @default.
- W2031284310 cites W2045184737 @default.
- W2031284310 cites W2045242880 @default.
- W2031284310 cites W2045389109 @default.
- W2031284310 cites W2046680687 @default.
- W2031284310 cites W2047330711 @default.
- W2031284310 cites W2047694154 @default.
- W2031284310 cites W2048399566 @default.
- W2031284310 cites W2053199655 @default.
- W2031284310 cites W2053552125 @default.
- W2031284310 cites W2054490779 @default.
- W2031284310 cites W2055173005 @default.
- W2031284310 cites W2057279358 @default.
- W2031284310 cites W2058218433 @default.
- W2031284310 cites W2059110133 @default.
- W2031284310 cites W2059198233 @default.
- W2031284310 cites W2059499071 @default.
- W2031284310 cites W2061440944 @default.
- W2031284310 cites W2061975273 @default.
- W2031284310 cites W2065059240 @default.
- W2031284310 cites W2067089521 @default.