FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031291239> ?p ?o ?g. }

• W2031291239 endingPage "23528" @default.
• W2031291239 startingPage "23518" @default.
• W2031291239 abstract "Intermediate amyloidogenic states along the amyloid β peptide (Aβ) aggregation pathway have been shown to be linked to neurotoxicity. To shed more light on the different structures that may arise during Aβ aggregation, we here investigate surfactant-induced Aβ aggregation. This process leads to co-aggregates featuring a β-structure motif that is characteristic for mature amyloid-like structures. Surfactants induce secondary structure in Aβ in a concentration-dependent manner, from predominantly random coil at low surfactant concentration, via β-structure to the fully formed α-helical state at high surfactant concentration. The β-rich state is the most aggregation-prone as monitored by thioflavin T fluorescence. Small angle x-ray scattering reveals initial globular structures of surfactant-Aβ co-aggregated oligomers and formation of elongated fibrils during a slow aggregation process. Alongside this slow (minutes to hours time scale) fibrillation process, much faster dynamic exchange (k(ex) ∼1100 s(-1)) takes place between free and co-aggregate-bound peptide. The two hydrophobic segments of the peptide are directly involved in the chemical exchange and interact with the hydrophobic part of the co-aggregates. Our findings suggest a model for surfactant-induced aggregation where free peptide and surfactant initially co-aggregate to dynamic globular oligomers and eventually form elongated fibrils. When interacting with β-structure promoting substances, such as surfactants, Aβ is kinetically driven toward an aggregation-prone state." @default.
• W2031291239 created "2016-06-24" @default.
• W2031291239 creator A5024744284 @default.
• W2031291239 creator A5034635485 @default.
• W2031291239 creator A5044813320 @default.
• W2031291239 creator A5046458072 @default.
• W2031291239 creator A5061366117 @default.
• W2031291239 creator A5069178435 @default.
• W2031291239 creator A5075943573 @default.
• W2031291239 creator A5076002285 @default.
• W2031291239 creator A5082229439 @default.
• W2031291239 date "2013-08-01" @default.
• W2031291239 modified "2023-10-12" @default.
• W2031291239 title "Formation of Dynamic Soluble Surfactant-induced Amyloid β Peptide Aggregation Intermediates" @default.
• W2031291239 cites W1482247849 @default.
• W2031291239 cites W1575285231 @default.
• W2031291239 cites W1602771322 @default.
• W2031291239 cites W1975082963 @default.
• W2031291239 cites W1976506921 @default.
• W2031291239 cites W1977802438 @default.
• W2031291239 cites W1977920759 @default.
• W2031291239 cites W1980825524 @default.
• W2031291239 cites W1981342080 @default.
• W2031291239 cites W1981580199 @default.
• W2031291239 cites W1986800510 @default.
• W2031291239 cites W1987686455 @default.
• W2031291239 cites W1993053769 @default.
• W2031291239 cites W1994939140 @default.
• W2031291239 cites W1997094739 @default.
• W2031291239 cites W1999839318 @default.
• W2031291239 cites W2001842463 @default.
• W2031291239 cites W2015927989 @default.
• W2031291239 cites W2020970511 @default.
• W2031291239 cites W2025187028 @default.
• W2031291239 cites W2025595434 @default.
• W2031291239 cites W2027863241 @default.
• W2031291239 cites W2028557939 @default.
• W2031291239 cites W2028688489 @default.
• W2031291239 cites W2030447611 @default.
• W2031291239 cites W2031218856 @default.
• W2031291239 cites W2033182544 @default.
• W2031291239 cites W2036946816 @default.
• W2031291239 cites W2039706105 @default.
• W2031291239 cites W2039730851 @default.
• W2031291239 cites W2039735363 @default.
• W2031291239 cites W2041724513 @default.
• W2031291239 cites W2046757827 @default.
• W2031291239 cites W2051907594 @default.
• W2031291239 cites W2059315933 @default.
• W2031291239 cites W2062071602 @default.
• W2031291239 cites W2067214887 @default.
• W2031291239 cites W2068918178 @default.
• W2031291239 cites W2070017758 @default.
• W2031291239 cites W2074009695 @default.
• W2031291239 cites W2075943744 @default.
• W2031291239 cites W2079852318 @default.
• W2031291239 cites W2080225612 @default.
• W2031291239 cites W2088480703 @default.
• W2031291239 cites W2088577455 @default.
• W2031291239 cites W2092985952 @default.
• W2031291239 cites W2094253502 @default.
• W2031291239 cites W2094881767 @default.
• W2031291239 cites W2101614182 @default.
• W2031291239 cites W2103298870 @default.
• W2031291239 cites W2115549726 @default.
• W2031291239 cites W2122294662 @default.
• W2031291239 cites W2123606696 @default.
• W2031291239 cites W2137276641 @default.
• W2031291239 cites W2138375082 @default.
• W2031291239 cites W2138587025 @default.
• W2031291239 cites W2138619586 @default.
• W2031291239 cites W2140389961 @default.
• W2031291239 cites W2144535585 @default.
• W2031291239 cites W2149478284 @default.
• W2031291239 cites W2160462930 @default.
• W2031291239 cites W2165186407 @default.
• W2031291239 cites W30334872 @default.
• W2031291239 doi "https://doi.org/10.1074/jbc.m113.470450" @default.
• W2031291239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5395029" @default.
• W2031291239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23775077" @default.
• W2031291239 hasPublicationYear "2013" @default.
• W2031291239 type Work @default.
• W2031291239 sameAs 2031291239 @default.
• W2031291239 citedByCount "42" @default.
• W2031291239 countsByYear W20312912392013 @default.
• W2031291239 countsByYear W20312912392014 @default.
• W2031291239 countsByYear W20312912392015 @default.
• W2031291239 countsByYear W20312912392016 @default.
• W2031291239 countsByYear W20312912392017 @default.
• W2031291239 countsByYear W20312912392018 @default.
• W2031291239 countsByYear W20312912392019 @default.
• W2031291239 countsByYear W20312912392020 @default.
• W2031291239 countsByYear W20312912392021 @default.
• W2031291239 countsByYear W20312912392022 @default.
• W2031291239 countsByYear W20312912392023 @default.
• W2031291239 crossrefType "journal-article" @default.
• W2031291239 hasAuthorship W2031291239A5024744284 @default.
• W2031291239 hasAuthorship W2031291239A5034635485 @default.

• next