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- W2031307002 abstract "Despite remarkable progress in the curative treatment approaches of several types of neoplastic diseases even in initial or subsequent disseminated stages the prognostic outcome of the great majority of adult cancer patients, once the disease has developed metastatic spread, is very limited. More than 500,000 people in the Unites States of America and even more in Europe and in Asia die each year of progressive, incurable cancer [l]. This is remarkably different in childhood and adolescent neoplastic disease, where today the majority of patients become long-term survivors, although to some variable extent with pronounced qualitative somatic and psychological sequelae in their future [2,3]. The cancer types prevailing in adults after 50 years are mostly slow-growing solid tumours, especially adeno-carcinomas such as gastrointestinal, lung or kidney cancer, that are biologically disinclined to respond easily to the present armamentarium of mostly cell cycle-dependent antineoplastic agents. In addition, a large proportion of these adult cancer patients report to physicians too late in their disease evolution and are already in an advanced stage at diagnosis, as we do not yet have an effective means for either primary or effective secondary prevention of most malignant visceral tumour types. Most treatment approaches in adult cancer patients with progressive incurable cancer types are therefore ‘palliative’, directed to prevent and treat unnecessary suffering of these patients on their way to a premature death [4]." @default.
- W2031307002 created "2016-06-24" @default.
- W2031307002 creator A5023895170 @default.
- W2031307002 date "2001-10-01" @default.
- W2031307002 modified "2023-09-27" @default.
- W2031307002 title "Optimal comprehensive symptom control: an overall strategy" @default.
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- W2031307002 doi "https://doi.org/10.1016/s0959-8049(01)80030-7" @default.
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