Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031322186> ?p ?o ?g. }
- W2031322186 endingPage "802" @default.
- W2031322186 startingPage "793" @default.
- W2031322186 abstract "A new paradigm is becoming widely accepted, that chronic inflammation, driven in part by chemokines and cytokines at the site of a tumour, may facilitate tumour progression instead of promoting anti-tumour immunity. Tumours and activated stromal cells secrete pro-inflammatory chemokines and cytokines that act either directly or indirectly through stimulation of the vascular endothelium to recruit leukocytes to the tumour. After activation, these tumour-associated leukocytes release angiogenic factors, mitogens, proteolytic enzymes, and chemotactic factors, recruiting more inflammatory cells and stimulating angiogenesis to sustain tumour growth and facilitate tumour metastasis. Breaking this cycle by inhibiting targets such as cytokines, chemokines and other inflammatory mediators, either alone, or more realistically, in combination with other therapies, such as anti-angiogenic or cytotoxic agents, may provide highly efficacious therapeutic regimens for the treatment of malignancies. This article reviews anti-cytokine and anti-chemokine therapies being pursued in cancer, and discusses in more detail anti-tumour necrosis factor-α (TNF) approaches." @default.
- W2031322186 created "2016-06-24" @default.
- W2031322186 creator A5000095164 @default.
- W2031322186 creator A5061685479 @default.
- W2031322186 creator A5075556432 @default.
- W2031322186 creator A5079612220 @default.
- W2031322186 date "2006-04-01" @default.
- W2031322186 modified "2023-10-13" @default.
- W2031322186 title "Therapeutic potential of cytokine and chemokine antagonists in cancer therapy" @default.
- W2031322186 cites W1501675811 @default.
- W2031322186 cites W1532384917 @default.
- W2031322186 cites W1548997088 @default.
- W2031322186 cites W1809740262 @default.
- W2031322186 cites W1840567140 @default.
- W2031322186 cites W1894837930 @default.
- W2031322186 cites W1940514332 @default.
- W2031322186 cites W1944909911 @default.
- W2031322186 cites W1970336778 @default.
- W2031322186 cites W1973220859 @default.
- W2031322186 cites W1978541038 @default.
- W2031322186 cites W1988390873 @default.
- W2031322186 cites W1989762708 @default.
- W2031322186 cites W1990777711 @default.
- W2031322186 cites W1994686202 @default.
- W2031322186 cites W1995212041 @default.
- W2031322186 cites W1995515383 @default.
- W2031322186 cites W2000946071 @default.
- W2031322186 cites W2008869575 @default.
- W2031322186 cites W2023772270 @default.
- W2031322186 cites W2023907053 @default.
- W2031322186 cites W2026425720 @default.
- W2031322186 cites W2027279302 @default.
- W2031322186 cites W2027887689 @default.
- W2031322186 cites W2029790299 @default.
- W2031322186 cites W2032386695 @default.
- W2031322186 cites W2032938314 @default.
- W2031322186 cites W2034936705 @default.
- W2031322186 cites W2036723263 @default.
- W2031322186 cites W2041056400 @default.
- W2031322186 cites W2042774683 @default.
- W2031322186 cites W2044486416 @default.
- W2031322186 cites W2044674091 @default.
- W2031322186 cites W2045789990 @default.
- W2031322186 cites W2046678626 @default.
- W2031322186 cites W2048141239 @default.
- W2031322186 cites W2048657818 @default.
- W2031322186 cites W2052088499 @default.
- W2031322186 cites W2053403380 @default.
- W2031322186 cites W2056918364 @default.
- W2031322186 cites W2058894435 @default.
- W2031322186 cites W2061114783 @default.
- W2031322186 cites W2065629710 @default.
- W2031322186 cites W2066521125 @default.
- W2031322186 cites W2066810823 @default.
- W2031322186 cites W2069736783 @default.
- W2031322186 cites W207000493 @default.
- W2031322186 cites W2071926914 @default.
- W2031322186 cites W2073472691 @default.
- W2031322186 cites W2076277955 @default.
- W2031322186 cites W2077765749 @default.
- W2031322186 cites W2081367726 @default.
- W2031322186 cites W2081573816 @default.
- W2031322186 cites W2082007625 @default.
- W2031322186 cites W2085430654 @default.
- W2031322186 cites W2091135137 @default.
- W2031322186 cites W2092816381 @default.
- W2031322186 cites W2101217954 @default.
- W2031322186 cites W2102790879 @default.
- W2031322186 cites W2108088303 @default.
- W2031322186 cites W2110734511 @default.
- W2031322186 cites W2116096217 @default.
- W2031322186 cites W2117419759 @default.
- W2031322186 cites W2119526257 @default.
- W2031322186 cites W2120800817 @default.
- W2031322186 cites W2123857513 @default.
- W2031322186 cites W2124093732 @default.
- W2031322186 cites W2124360707 @default.
- W2031322186 cites W2124514001 @default.
- W2031322186 cites W2125657144 @default.
- W2031322186 cites W2127281820 @default.
- W2031322186 cites W2130927569 @default.
- W2031322186 cites W2131652664 @default.
- W2031322186 cites W2133846971 @default.
- W2031322186 cites W2142219378 @default.
- W2031322186 cites W2142728202 @default.
- W2031322186 cites W2144239947 @default.
- W2031322186 cites W2149958200 @default.
- W2031322186 cites W2152190150 @default.
- W2031322186 cites W2156323704 @default.
- W2031322186 cites W2164394800 @default.
- W2031322186 cites W2165885713 @default.
- W2031322186 cites W2169004170 @default.
- W2031322186 cites W2169594043 @default.
- W2031322186 cites W2248549259 @default.
- W2031322186 cites W2316160054 @default.
- W2031322186 cites W2318706214 @default.
- W2031322186 cites W2473041787 @default.
- W2031322186 cites W4253664038 @default.