Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031326591> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2031326591 abstract "To determine the role of VIP-like peptides on neurotransmission of vagus nerve, we evaluated the effects of helodermin, helospectin, and vasoactive intestinal peptide (VIP) on the contraction of guinea pig tracheal smooth muscle evoked by electrical field stimulation (EFS) or the exogenous application of actylcholine (ACh). Isometric tension of tracheal strips was measured in the presence of indomethacin (10(-6) M) and of guanethidine (10(-6) M). VIP (10(-9) M to 10(-7) M) significantly suppressed the contraction evoked by EFS. VIP, at concentrations of 10(-9) M and 10(-8) M, did not affect the ACh-evoked contraction, but a concentration of 10(-7) M suppressed ACh-evoked contraction. Helospectin and helodermin (10(-8) M and 10(-7) M) significantly suppressed the EFS-evoked contraction, but 10(-9) M showed no effect. Helospectin and helodermin had no effect on the ACh sensitivity of smooth muscle up to 10(-8) M, but a concentration of 10(-7) M suppressed the ACh-evoked contraction. These results indicate that helodermin, helospectin, and VIP exert both pre- and post-junctional inhibitory effects on the airway smooth muscle of guinea pigs. These peptides, thus, inhibited tracheal smooth muscle contraction prejunctionally at low concentrations, and acted postjunctionally at higher concentrations." @default.
- W2031326591 created "2016-06-24" @default.
- W2031326591 creator A5010166979 @default.
- W2031326591 creator A5019750455 @default.
- W2031326591 creator A5030508934 @default.
- W2031326591 creator A5041288783 @default.
- W2031326591 creator A5065564013 @default.
- W2031326591 creator A5088519518 @default.
- W2031326591 date "1997-01-01" @default.
- W2031326591 modified "2023-09-26" @default.
- W2031326591 title "Pre- and Post-Junctional Effects of VIP-Like Peptides in Guinea Pig Tracheal Smooth Muscle" @default.
- W2031326591 doi "https://doi.org/10.1159/000196644" @default.
- W2031326591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9044477" @default.
- W2031326591 hasPublicationYear "1997" @default.
- W2031326591 type Work @default.
- W2031326591 sameAs 2031326591 @default.
- W2031326591 citedByCount "2" @default.
- W2031326591 crossrefType "journal-article" @default.
- W2031326591 hasAuthorship W2031326591A5010166979 @default.
- W2031326591 hasAuthorship W2031326591A5019750455 @default.
- W2031326591 hasAuthorship W2031326591A5030508934 @default.
- W2031326591 hasAuthorship W2031326591A5041288783 @default.
- W2031326591 hasAuthorship W2031326591A5065564013 @default.
- W2031326591 hasAuthorship W2031326591A5088519518 @default.
- W2031326591 hasConcept C103486182 @default.
- W2031326591 hasConcept C118303440 @default.
- W2031326591 hasConcept C126322002 @default.
- W2031326591 hasConcept C134018914 @default.
- W2031326591 hasConcept C163415756 @default.
- W2031326591 hasConcept C170493617 @default.
- W2031326591 hasConcept C24998067 @default.
- W2031326591 hasConcept C2775910092 @default.
- W2031326591 hasConcept C2776050358 @default.
- W2031326591 hasConcept C2776232365 @default.
- W2031326591 hasConcept C2776533618 @default.
- W2031326591 hasConcept C2777056410 @default.
- W2031326591 hasConcept C2778815084 @default.
- W2031326591 hasConcept C71924100 @default.
- W2031326591 hasConcept C8330315 @default.
- W2031326591 hasConceptScore W2031326591C103486182 @default.
- W2031326591 hasConceptScore W2031326591C118303440 @default.
- W2031326591 hasConceptScore W2031326591C126322002 @default.
- W2031326591 hasConceptScore W2031326591C134018914 @default.
- W2031326591 hasConceptScore W2031326591C163415756 @default.
- W2031326591 hasConceptScore W2031326591C170493617 @default.
- W2031326591 hasConceptScore W2031326591C24998067 @default.
- W2031326591 hasConceptScore W2031326591C2775910092 @default.
- W2031326591 hasConceptScore W2031326591C2776050358 @default.
- W2031326591 hasConceptScore W2031326591C2776232365 @default.
- W2031326591 hasConceptScore W2031326591C2776533618 @default.
- W2031326591 hasConceptScore W2031326591C2777056410 @default.
- W2031326591 hasConceptScore W2031326591C2778815084 @default.
- W2031326591 hasConceptScore W2031326591C71924100 @default.
- W2031326591 hasConceptScore W2031326591C8330315 @default.
- W2031326591 hasLocation W20313265911 @default.
- W2031326591 hasLocation W20313265912 @default.
- W2031326591 hasOpenAccess W2031326591 @default.
- W2031326591 hasPrimaryLocation W20313265911 @default.
- W2031326591 hasRelatedWork W1968151311 @default.
- W2031326591 hasRelatedWork W2023924805 @default.
- W2031326591 hasRelatedWork W2044397795 @default.
- W2031326591 hasRelatedWork W2088160386 @default.
- W2031326591 hasRelatedWork W2093101585 @default.
- W2031326591 hasRelatedWork W2103452934 @default.
- W2031326591 hasRelatedWork W2112845103 @default.
- W2031326591 hasRelatedWork W2156191117 @default.
- W2031326591 hasRelatedWork W2203629035 @default.
- W2031326591 hasRelatedWork W3098292828 @default.
- W2031326591 isParatext "false" @default.
- W2031326591 isRetracted "false" @default.
- W2031326591 magId "2031326591" @default.
- W2031326591 workType "article" @default.