FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031328832> ?p ?o ?g. }

• W2031328832 endingPage "704" @default.
• W2031328832 startingPage "700" @default.
• W2031328832 abstract "To assess the effect of alpha-interferon therapy on hepatitis C viral RNA in serum of patients with chronic hepatitis C.Retrospective testing for hepatitis C viral (HCV) RNA and antibody to the hepatitis C virus (anti-HCV) of stored serum samples from a randomized, double-blind, placebo-controlled trial of alpha-interferon therapy.Warren Grant Magnuson Clinical Center of the National Institutes of Health, a tertiary referral center.Forty-one patients with chronic non-A, non-B hepatitis were entered in this trial.Twenty-one patients were treated with alpha-interferon, and 20 patients were treated with placebo for 6 months. Seventeen placebo recipients were then treated with alpha-interferon for up to 1 year.Samples were tested for anti-HCV by enzyme-linked immunosorbent assay. Hepatitis C viral RNA was detected in serum using the polymerase chain reaction. Titers of both antibody and RNA were determined by serial end-point dilution.At entry into the trial, 37 (90%) of 41 patients had anti-HCV and 39 (95%) had HCV RNA in serum. Anti-HCV titers decreased slightly with treatment. Serum levels of HCV RNA decreased in all patients who responded to alpha-interferon therapy with improvements in serum aminotransferases; in 17 of 21 responders (81%; 95% Cl, 58% to 95%) HCV RNA became undetectable. In contrast, in only 2 of 16 (12%; Cl, 2% to 38%) patients who did not respond to treatment did HCV RNA become undetectable. In 19 patients treated during the preliminary 6-month period with placebo, HCV RNA remained detectable. Finally, in the 11 patients who relapsed when treatment was stopped, HCV RNA reappeared in the serum, but in 4 of 7 patients with a sustained improvement in serum aminotransferases, HCV RNA remained undetectable.These results indicate that the clinical and serum biochemical response to alpha-interferon in chronic hepatitis C is associated with a loss of detectable HCV genome from serum." @default.
• W2031328832 created "2016-06-24" @default.
• W2031328832 creator A5022731052 @default.
• W2031328832 creator A5035898518 @default.
• W2031328832 creator A5048209504 @default.
• W2031328832 creator A5066169019 @default.
• W2031328832 creator A5067988074 @default.
• W2031328832 creator A5069191697 @default.
• W2031328832 creator A5078068605 @default.
• W2031328832 date "1991-11-01" @default.
• W2031328832 modified "2023-10-06" @default.
• W2031328832 title "Decrease in Serum Hepatitis C Viral RNA during Alpha-Interferon Therapy for Chronic Hepatitis C" @default.
• W2031328832 cites W1974879228 @default.
• W2031328832 cites W2000124886 @default.
• W2031328832 cites W2004419588 @default.
• W2031328832 cites W2006309458 @default.
• W2031328832 cites W2027655764 @default.
• W2031328832 cites W2027673360 @default.
• W2031328832 cites W2030041350 @default.
• W2031328832 cites W2031465792 @default.
• W2031328832 cites W2047480444 @default.
• W2031328832 cites W2048510206 @default.
• W2031328832 cites W2066124462 @default.
• W2031328832 cites W2123135658 @default.
• W2031328832 cites W2163131045 @default.
• W2031328832 cites W2165837877 @default.
• W2031328832 cites W2324539587 @default.
• W2031328832 cites W2334197314 @default.
• W2031328832 cites W2336799715 @default.
• W2031328832 doi "https://doi.org/10.7326/0003-4819-115-9-700" @default.
• W2031328832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1656828" @default.
• W2031328832 hasPublicationYear "1991" @default.
• W2031328832 type Work @default.
• W2031328832 sameAs 2031328832 @default.
• W2031328832 citedByCount "368" @default.
• W2031328832 countsByYear W20313288322012 @default.
• W2031328832 countsByYear W20313288322013 @default.
• W2031328832 countsByYear W20313288322015 @default.
• W2031328832 countsByYear W20313288322016 @default.
• W2031328832 countsByYear W20313288322018 @default.
• W2031328832 countsByYear W20313288322019 @default.
• W2031328832 countsByYear W20313288322020 @default.
• W2031328832 countsByYear W20313288322021 @default.
• W2031328832 countsByYear W20313288322022 @default.
• W2031328832 countsByYear W20313288322023 @default.
• W2031328832 crossrefType "journal-article" @default.
• W2031328832 hasAuthorship W2031328832A5022731052 @default.
• W2031328832 hasAuthorship W2031328832A5035898518 @default.
• W2031328832 hasAuthorship W2031328832A5048209504 @default.
• W2031328832 hasAuthorship W2031328832A5066169019 @default.
• W2031328832 hasAuthorship W2031328832A5067988074 @default.
• W2031328832 hasAuthorship W2031328832A5069191697 @default.
• W2031328832 hasAuthorship W2031328832A5078068605 @default.
• W2031328832 hasConcept C126322002 @default.
• W2031328832 hasConcept C142462285 @default.
• W2031328832 hasConcept C142724271 @default.
• W2031328832 hasConcept C159047783 @default.
• W2031328832 hasConcept C159654299 @default.
• W2031328832 hasConcept C203014093 @default.
• W2031328832 hasConcept C204787440 @default.
• W2031328832 hasConcept C2522874641 @default.
• W2031328832 hasConcept C27081682 @default.
• W2031328832 hasConcept C2776178377 @default.
• W2031328832 hasConcept C2776408679 @default.
• W2031328832 hasConcept C2776455275 @default.
• W2031328832 hasConcept C2781228144 @default.
• W2031328832 hasConcept C2909179924 @default.
• W2031328832 hasConcept C32611913 @default.
• W2031328832 hasConcept C71924100 @default.
• W2031328832 hasConcept C90924648 @default.
• W2031328832 hasConceptScore W2031328832C126322002 @default.
• W2031328832 hasConceptScore W2031328832C142462285 @default.
• W2031328832 hasConceptScore W2031328832C142724271 @default.
• W2031328832 hasConceptScore W2031328832C159047783 @default.
• W2031328832 hasConceptScore W2031328832C159654299 @default.
• W2031328832 hasConceptScore W2031328832C203014093 @default.
• W2031328832 hasConceptScore W2031328832C204787440 @default.
• W2031328832 hasConceptScore W2031328832C2522874641 @default.
• W2031328832 hasConceptScore W2031328832C27081682 @default.
• W2031328832 hasConceptScore W2031328832C2776178377 @default.
• W2031328832 hasConceptScore W2031328832C2776408679 @default.
• W2031328832 hasConceptScore W2031328832C2776455275 @default.
• W2031328832 hasConceptScore W2031328832C2781228144 @default.
• W2031328832 hasConceptScore W2031328832C2909179924 @default.
• W2031328832 hasConceptScore W2031328832C32611913 @default.
• W2031328832 hasConceptScore W2031328832C71924100 @default.
• W2031328832 hasConceptScore W2031328832C90924648 @default.
• W2031328832 hasIssue "9" @default.
• W2031328832 hasLocation W20313288321 @default.
• W2031328832 hasLocation W20313288322 @default.
• W2031328832 hasOpenAccess W2031328832 @default.
• W2031328832 hasPrimaryLocation W20313288321 @default.
• W2031328832 hasRelatedWork W2004314479 @default.
• W2031328832 hasRelatedWork W2010577532 @default.
• W2031328832 hasRelatedWork W2050318447 @default.
• W2031328832 hasRelatedWork W2061573700 @default.
• W2031328832 hasRelatedWork W2062901722 @default.
• W2031328832 hasRelatedWork W2070480238 @default.

• next