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- W2031330652 abstract "In order to investigate the possibility of predicting malignant transformation of oral precancerous lesions in the initial biopsy specimens, Feulgen-DNA cytofluorometry was applied to the initial biopsies of 7 cases of leukoplakia and one of lichen planus which later showed malignant transformation, using smears of squamous epithelial cells isolated from thick paraffin sections with non-specific fluorescence blocking. Analysis of DNA ploidy patterns revealed that “dysplastic changes” of DNA histograms in cases with epithelial dysplasia tended to be expressed by a shift of the modal peak to hyperdiploid values and by an increased number of cells in 2.5 C to 3.5 C and hyper-4 C, regardless of the prognosis. However, in the cases with subsequent malignant transformation, the DNA histogram was characterized by the appearance of bimodal peaks." @default.
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- W2031330652 date "1983-03-01" @default.
- W2031330652 modified "2023-10-16" @default.
- W2031330652 title "Prediction of malignant change in oral precancerous lesions by DNA cytofluorometry" @default.
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- W2031330652 doi "https://doi.org/10.1111/j.1600-0714.1983.tb00322.x" @default.
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