Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031334428> ?p ?o ?g. }
- W2031334428 endingPage "1254" @default.
- W2031334428 startingPage "1248" @default.
- W2031334428 abstract "Idiopathic pulmonary fibrosis is characterized by myofibroblast accumulation, extracellular matrix (ECM) remodeling, and excessive collagen deposition. ECM-producing myofibroblasts may originate from epithelial cells through epithelial to mesenchymal transition (EMT). TGF-β1 is an inducer of EMT in pulmonary epithelial cells in vitro and in vivo, though the mechanisms are unclear. We hypothesized that TGF-β1 induced EMT through Smad-dependent and -independent processes. To test this hypothesis, we studied the roles and mechanisms of TGF-β1-induced Smad and p38 mitogen-activated protein kinase (MAPK) signaling in EMT-related changes in pulmonary epithelial cells. Exposure of pulmonary epithelial 1HAEo− cells to TGF-β1 resulted in morphological and molecular changes of EMT over a 96-h period; loss of cell–cell contact, cell elongation, down-regulation of E-cadherin, up-regulation of fibronectin, and up-regulation of collagen I. Both Smad2/3 and p38 MAPK signaling pathways were activated by TGF-β1. However, neither Smad2/3 nor p38 MAPK were required for the down-regulation of E-cadherin, yet p38 MAPK was associated with fibronectin up-regulation. Both Smad2/3 and p38 MAPK had a role in regulation of TGF-β1-induced collagen expression. Furthermore, these data demonstrate that Smads and p38 MAPK differentially regulate EMT-related changes in pulmonary epithelial cells. J. Cell. Physiol. 226: 1248–1254, 2011. © 2010 Wiley-Liss, Inc." @default.
- W2031334428 created "2016-06-24" @default.
- W2031334428 creator A5013484427 @default.
- W2031334428 creator A5019506336 @default.
- W2031334428 creator A5029497209 @default.
- W2031334428 date "2011-02-22" @default.
- W2031334428 modified "2023-10-02" @default.
- W2031334428 title "Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells" @default.
- W2031334428 cites W121287568 @default.
- W2031334428 cites W1498069273 @default.
- W2031334428 cites W1517079251 @default.
- W2031334428 cites W1577109401 @default.
- W2031334428 cites W1760933578 @default.
- W2031334428 cites W1840163537 @default.
- W2031334428 cites W1918709511 @default.
- W2031334428 cites W1930083400 @default.
- W2031334428 cites W1951049964 @default.
- W2031334428 cites W1972167901 @default.
- W2031334428 cites W1974926454 @default.
- W2031334428 cites W1988272762 @default.
- W2031334428 cites W1994798295 @default.
- W2031334428 cites W2000099153 @default.
- W2031334428 cites W2018809578 @default.
- W2031334428 cites W2019161121 @default.
- W2031334428 cites W2026620093 @default.
- W2031334428 cites W2046501504 @default.
- W2031334428 cites W2046656677 @default.
- W2031334428 cites W2047992261 @default.
- W2031334428 cites W2051812986 @default.
- W2031334428 cites W2060126259 @default.
- W2031334428 cites W2061476658 @default.
- W2031334428 cites W2062268212 @default.
- W2031334428 cites W2080239627 @default.
- W2031334428 cites W2082438422 @default.
- W2031334428 cites W2096879602 @default.
- W2031334428 cites W2099368049 @default.
- W2031334428 cites W2099950968 @default.
- W2031334428 cites W2103919722 @default.
- W2031334428 cites W2113638068 @default.
- W2031334428 cites W2113989947 @default.
- W2031334428 cites W2114274896 @default.
- W2031334428 cites W2118650242 @default.
- W2031334428 cites W2122808924 @default.
- W2031334428 cites W2123989622 @default.
- W2031334428 cites W2128571355 @default.
- W2031334428 cites W2134024560 @default.
- W2031334428 cites W2134931198 @default.
- W2031334428 cites W2136358097 @default.
- W2031334428 cites W2140923971 @default.
- W2031334428 cites W2149914697 @default.
- W2031334428 cites W2154568166 @default.
- W2031334428 cites W4250450758 @default.
- W2031334428 doi "https://doi.org/10.1002/jcp.22448" @default.
- W2031334428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3043117" @default.
- W2031334428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20945383" @default.
- W2031334428 hasPublicationYear "2011" @default.
- W2031334428 type Work @default.
- W2031334428 sameAs 2031334428 @default.
- W2031334428 citedByCount "115" @default.
- W2031334428 countsByYear W20313344282012 @default.
- W2031334428 countsByYear W20313344282013 @default.
- W2031334428 countsByYear W20313344282014 @default.
- W2031334428 countsByYear W20313344282015 @default.
- W2031334428 countsByYear W20313344282016 @default.
- W2031334428 countsByYear W20313344282017 @default.
- W2031334428 countsByYear W20313344282018 @default.
- W2031334428 countsByYear W20313344282019 @default.
- W2031334428 countsByYear W20313344282020 @default.
- W2031334428 countsByYear W20313344282021 @default.
- W2031334428 countsByYear W20313344282022 @default.
- W2031334428 countsByYear W20313344282023 @default.
- W2031334428 crossrefType "journal-article" @default.
- W2031334428 hasAuthorship W2031334428A5013484427 @default.
- W2031334428 hasAuthorship W2031334428A5019506336 @default.
- W2031334428 hasAuthorship W2031334428A5029497209 @default.
- W2031334428 hasBestOaLocation W20313344282 @default.
- W2031334428 hasConcept C104317684 @default.
- W2031334428 hasConcept C118131993 @default.
- W2031334428 hasConcept C126322002 @default.
- W2031334428 hasConcept C127561419 @default.
- W2031334428 hasConcept C184235292 @default.
- W2031334428 hasConcept C185592680 @default.
- W2031334428 hasConcept C189165786 @default.
- W2031334428 hasConcept C207865475 @default.
- W2031334428 hasConcept C2780559512 @default.
- W2031334428 hasConcept C2781080636 @default.
- W2031334428 hasConcept C2781244666 @default.
- W2031334428 hasConcept C51551487 @default.
- W2031334428 hasConcept C55493867 @default.
- W2031334428 hasConcept C57074206 @default.
- W2031334428 hasConcept C62478195 @default.
- W2031334428 hasConcept C71924100 @default.
- W2031334428 hasConcept C76419328 @default.
- W2031334428 hasConcept C86492073 @default.
- W2031334428 hasConcept C86803240 @default.
- W2031334428 hasConcept C95444343 @default.
- W2031334428 hasConcept C97029542 @default.
- W2031334428 hasConceptScore W2031334428C104317684 @default.