FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031342316> ?p ?o ?g. }

• W2031342316 endingPage "128" @default.
• W2031342316 startingPage "115" @default.
• W2031342316 abstract "The majority of eukaryotic pre-mRNAs are processed by 3'-end cleavage and polyadenylation, although in metazoa the replication-dependent histone mRNAs are processed by 3'-end cleavage but not polyadenylation. The macromolecular complex responsible for processing both canonical and histone pre-mRNAs contains the approximately 1160-residue protein Symplekin. Secondary-structural prediction algorithms identified putative HEAT domains in the 300 N-terminal residues of all Symplekins of known sequence. The structure and dynamics of this domain were investigated to begin elucidating the role Symplekin plays in mRNA maturation. The crystal structure of the Drosophila melanogaster Symplekin HEAT domain was determined to 2.4 A resolution with single-wavelength anomalous dispersion phasing methods. The structure exhibits five canonical HEAT repeats along with an extended 31-amino-acid loop (loop 8) between the fourth and fifth repeat that is conserved within closely related Symplekin sequences. Molecular dynamics simulations of this domain show that the presence of loop 8 dampens correlated and anticorrelated motion in the HEAT domain, therefore providing a neutral surface for potential protein-protein interactions. HEAT domains are often employed for such macromolecular contacts. The Symplekin HEAT region not only structurally aligns with several established scaffolding proteins, but also has been reported to contact proteins essential for regulating 3'-end processing. Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process." @default.
• W2031342316 created "2016-06-24" @default.
• W2031342316 creator A5010243917 @default.
• W2031342316 creator A5012990749 @default.
• W2031342316 creator A5027786475 @default.
• W2031342316 creator A5041494111 @default.
• W2031342316 creator A5047703823 @default.
• W2031342316 creator A5056183841 @default.
• W2031342316 date "2009-09-01" @default.
• W2031342316 modified "2023-09-27" @default.
• W2031342316 title "Crystal Structure of the HEAT Domain from the Pre-mRNA Processing Factor Symplekin" @default.
• W2031342316 cites W1493069978 @default.
• W2031342316 cites W1595801567 @default.
• W2031342316 cites W1967109444 @default.
• W2031342316 cites W1969007008 @default.
• W2031342316 cites W1971361691 @default.
• W2031342316 cites W1971990705 @default.
• W2031342316 cites W1972208485 @default.
• W2031342316 cites W1976499671 @default.
• W2031342316 cites W1977599918 @default.
• W2031342316 cites W1993800020 @default.
• W2031342316 cites W1999805448 @default.
• W2031342316 cites W2013286714 @default.
• W2031342316 cites W2020204531 @default.
• W2031342316 cites W2020541498 @default.
• W2031342316 cites W2020721543 @default.
• W2031342316 cites W2022366078 @default.
• W2031342316 cites W2023790301 @default.
• W2031342316 cites W2024645073 @default.
• W2031342316 cites W2028320405 @default.
• W2031342316 cites W2030651372 @default.
• W2031342316 cites W2035687084 @default.
• W2031342316 cites W2038424676 @default.
• W2031342316 cites W2045999651 @default.
• W2031342316 cites W2047245819 @default.
• W2031342316 cites W2060259273 @default.
• W2031342316 cites W2062584177 @default.
• W2031342316 cites W2074986801 @default.
• W2031342316 cites W2082389145 @default.
• W2031342316 cites W2083462984 @default.
• W2031342316 cites W2084466582 @default.
• W2031342316 cites W2085037886 @default.
• W2031342316 cites W2092132819 @default.
• W2031342316 cites W2092670169 @default.
• W2031342316 cites W2093295511 @default.
• W2031342316 cites W2094021381 @default.
• W2031342316 cites W2097382368 @default.
• W2031342316 cites W2098512408 @default.
• W2031342316 cites W2107176055 @default.
• W2031342316 cites W2109235554 @default.
• W2031342316 cites W2110863368 @default.
• W2031342316 cites W2111403104 @default.
• W2031342316 cites W2111802043 @default.
• W2031342316 cites W2116423958 @default.
• W2031342316 cites W2117326599 @default.
• W2031342316 cites W2117582851 @default.
• W2031342316 cites W2118233996 @default.
• W2031342316 cites W2120527610 @default.
• W2031342316 cites W2122609893 @default.
• W2031342316 cites W2125617798 @default.
• W2031342316 cites W2126361876 @default.
• W2031342316 cites W2127071252 @default.
• W2031342316 cites W2131824470 @default.
• W2031342316 cites W2133812171 @default.
• W2031342316 cites W2136280642 @default.
• W2031342316 cites W2139044529 @default.
• W2031342316 cites W2139253560 @default.
• W2031342316 cites W2144081223 @default.
• W2031342316 cites W2146719608 @default.
• W2031342316 cites W2152470748 @default.
• W2031342316 cites W2152807182 @default.
• W2031342316 cites W2156678798 @default.
• W2031342316 cites W2158714788 @default.
• W2031342316 cites W2162816788 @default.
• W2031342316 doi "https://doi.org/10.1016/j.jmb.2009.06.062" @default.
• W2031342316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2748850" @default.
• W2031342316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19576221" @default.
• W2031342316 hasPublicationYear "2009" @default.
• W2031342316 type Work @default.
• W2031342316 sameAs 2031342316 @default.
• W2031342316 citedByCount "20" @default.
• W2031342316 countsByYear W20313423162012 @default.
• W2031342316 countsByYear W20313423162013 @default.
• W2031342316 countsByYear W20313423162014 @default.
• W2031342316 countsByYear W20313423162015 @default.
• W2031342316 countsByYear W20313423162016 @default.
• W2031342316 countsByYear W20313423162017 @default.
• W2031342316 countsByYear W20313423162018 @default.
• W2031342316 countsByYear W20313423162019 @default.
• W2031342316 countsByYear W20313423162020 @default.
• W2031342316 countsByYear W20313423162021 @default.
• W2031342316 countsByYear W20313423162023 @default.
• W2031342316 crossrefType "journal-article" @default.
• W2031342316 hasAuthorship W2031342316A5010243917 @default.
• W2031342316 hasAuthorship W2031342316A5012990749 @default.
• W2031342316 hasAuthorship W2031342316A5027786475 @default.
• W2031342316 hasAuthorship W2031342316A5041494111 @default.
• W2031342316 hasAuthorship W2031342316A5047703823 @default.

• next