Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031343589> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2031343589 endingPage "691" @default.
- W2031343589 startingPage "686" @default.
- W2031343589 abstract "Studies were undertaken to determine the formation of benzylic−DNA adducts in rats administered 7,12-dimethylbenz[a]anthracene (DMBA) and its meso-region metabolites by subcutaneous injection. Here, we show that 7-hydroxymethyl-12-methylbenz[a]anthracene (7-HMBA) and 7-sulfoxymethyl-12-methylbenz[a]anthracene (7-SMBA) gave rise to some benzylic−DNA adducts indistinguishable from adducts formed from DMBA. Adducts were analyzed by butanol enrichment-mediated 32P-postlabeling assay. Female Sprague−Dawley rats given a combined dose of 420 μmol DMBA/kg b. wt resulted in two major and up to nine minor adducts in the subcutaneous tissue, with chromatographic resemblance to benzylic−DNA adducts prepared in vitro. Subcutaneous administration of 7-HMBA, 7-SMBA, and 7-methyl-12-hydroxymethylbenz[a]anthracene (12-HMBA) (210, 42, and 210 μmol/kg b. wt, respectively) each resulted in one major and several minor benzylic−DNA adducts. From cochromatography with reference adducts, it was concluded that the benzylic DNA adduct 4, derived from the parent compound, comigrates with the major adduct from 7-HMBA and 7-SMBA, whereas adducts 2 and 3 comigrate with adducts resulting from 12-HMBA and 7-methyl-12-sulfooxymethylbenz[a]anthracene, respectively. These data suggest that 7-sulfooxymethyl- and 12-sulfooxymethy derivatives produce distinct adducts. Several major and minor diol epoxide-related DNA adducts were also detected. The diol epoxide− and benzylic−DNA adducts were found in a 2:1 ratio. The oral, intraperitoneal, and intramammiliary treatments with DMBA showed no detectable benzylic adducts in the liver and mammary glands 24 h after the last treatment, although the adduct formation was clearly evident with SMBA and/or HMBA treatments, suggesting that hydroxylation of DMBA to form HMBA may be the rate-limiting step for the meso-methyl substitution pathway. The present study clearly demonstrates the in vivo formation of benzylic−DNA adducts from DMBA. The data also reveal the involvement of the 12-methyl group of DMBA in adduct formation." @default.
- W2031343589 created "2016-06-24" @default.
- W2031343589 creator A5009847146 @default.
- W2031343589 creator A5020267991 @default.
- W2031343589 creator A5034970510 @default.
- W2031343589 creator A5048979196 @default.
- W2031343589 creator A5064916156 @default.
- W2031343589 date "2005-03-10" @default.
- W2031343589 modified "2023-09-27" @default.
- W2031343589 title "Formation of Benzylic−DNA Adducts Resulting from 7,12-Dimethylbenz[<i>a</i>]anthracene in Vivo" @default.
- W2031343589 cites W1970509125 @default.
- W2031343589 cites W1971815790 @default.
- W2031343589 cites W1976653254 @default.
- W2031343589 cites W2036415831 @default.
- W2031343589 cites W2048761548 @default.
- W2031343589 cites W2109941595 @default.
- W2031343589 cites W2117227109 @default.
- W2031343589 doi "https://doi.org/10.1021/tx049686p" @default.
- W2031343589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15833028" @default.
- W2031343589 hasPublicationYear "2005" @default.
- W2031343589 type Work @default.
- W2031343589 sameAs 2031343589 @default.
- W2031343589 citedByCount "7" @default.
- W2031343589 countsByYear W20313435892016 @default.
- W2031343589 countsByYear W20313435892019 @default.
- W2031343589 countsByYear W20313435892021 @default.
- W2031343589 crossrefType "journal-article" @default.
- W2031343589 hasAuthorship W2031343589A5009847146 @default.
- W2031343589 hasAuthorship W2031343589A5020267991 @default.
- W2031343589 hasAuthorship W2031343589A5034970510 @default.
- W2031343589 hasAuthorship W2031343589A5048979196 @default.
- W2031343589 hasAuthorship W2031343589A5064916156 @default.
- W2031343589 hasConcept C104317684 @default.
- W2031343589 hasConcept C108204754 @default.
- W2031343589 hasConcept C114246631 @default.
- W2031343589 hasConcept C150903083 @default.
- W2031343589 hasConcept C178790620 @default.
- W2031343589 hasConcept C185592680 @default.
- W2031343589 hasConcept C207001950 @default.
- W2031343589 hasConcept C2776260934 @default.
- W2031343589 hasConcept C2778938436 @default.
- W2031343589 hasConcept C2779515768 @default.
- W2031343589 hasConcept C2779563022 @default.
- W2031343589 hasConcept C552990157 @default.
- W2031343589 hasConcept C55493867 @default.
- W2031343589 hasConcept C555283112 @default.
- W2031343589 hasConcept C71240020 @default.
- W2031343589 hasConcept C75473681 @default.
- W2031343589 hasConcept C86803240 @default.
- W2031343589 hasConceptScore W2031343589C104317684 @default.
- W2031343589 hasConceptScore W2031343589C108204754 @default.
- W2031343589 hasConceptScore W2031343589C114246631 @default.
- W2031343589 hasConceptScore W2031343589C150903083 @default.
- W2031343589 hasConceptScore W2031343589C178790620 @default.
- W2031343589 hasConceptScore W2031343589C185592680 @default.
- W2031343589 hasConceptScore W2031343589C207001950 @default.
- W2031343589 hasConceptScore W2031343589C2776260934 @default.
- W2031343589 hasConceptScore W2031343589C2778938436 @default.
- W2031343589 hasConceptScore W2031343589C2779515768 @default.
- W2031343589 hasConceptScore W2031343589C2779563022 @default.
- W2031343589 hasConceptScore W2031343589C552990157 @default.
- W2031343589 hasConceptScore W2031343589C55493867 @default.
- W2031343589 hasConceptScore W2031343589C555283112 @default.
- W2031343589 hasConceptScore W2031343589C71240020 @default.
- W2031343589 hasConceptScore W2031343589C75473681 @default.
- W2031343589 hasConceptScore W2031343589C86803240 @default.
- W2031343589 hasIssue "4" @default.
- W2031343589 hasLocation W20313435891 @default.
- W2031343589 hasLocation W20313435892 @default.
- W2031343589 hasOpenAccess W2031343589 @default.
- W2031343589 hasPrimaryLocation W20313435891 @default.
- W2031343589 hasRelatedWork W1554537892 @default.
- W2031343589 hasRelatedWork W1972989989 @default.
- W2031343589 hasRelatedWork W1977323480 @default.
- W2031343589 hasRelatedWork W2031343589 @default.
- W2031343589 hasRelatedWork W2031774815 @default.
- W2031343589 hasRelatedWork W2047436289 @default.
- W2031343589 hasRelatedWork W2065431966 @default.
- W2031343589 hasRelatedWork W2085441875 @default.
- W2031343589 hasRelatedWork W2121309576 @default.
- W2031343589 hasRelatedWork W2168444622 @default.
- W2031343589 hasVolume "18" @default.
- W2031343589 isParatext "false" @default.
- W2031343589 isRetracted "false" @default.
- W2031343589 magId "2031343589" @default.
- W2031343589 workType "article" @default.