FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031350900> ?p ?o ?g. }

• W2031350900 endingPage "281" @default.
• W2031350900 startingPage "274" @default.
• W2031350900 abstract "Aims Nitric oxide (NO) may modulate myocardial ischaemia/reperfusion (I/R) injury, but effects of hypercholesterolaemia on myocardial NO release during I/R are unknown. Methods A NO-specific carbon fibre electrode continuously measured coronary sinus [NO] during 60 min low-flow ischaemia (1 ml/min) and 60 min free reperfusion (I/R) in isolated rabbit hearts. Experimental groups (n = 7 per group) were control, l-arginine supplement (200 μM), N-nitro-l-arginine methyl ester (L-NAME) treatment (8 μM) and hypercholesterolaemic. Results During early I, NO release decreased markedly in control (−1356 ± 286 pmol/min/g) and l-arginine (−1972 ± 172) groups, but less in L-NAME (−441 ± 89) and hypercholesterolaemic (−602 ± 164) groups (both p < 0.01 vs. controls). No increase in NO release during I was seen in any group. After R, NO release increased above baseline in control (+2333 ± 591 pmol/min/g) and l-arginine (+1048 ± 278) groups and hypercholesterolaemic (+1100 ± 478) (p < 0.05 vs. pre-ischaemia each group). There was little increase in NO release in the L-NAME group (+436 ± 247 pmol/min/g, p < 0.05 vs. controls). In each group, myocardial NO release declined towards pre-ischaemic levels during 60 min R. Hearts treated with l-arginine had similar NO release but better functional recovery than controls (p < 0.01). Treatment with L-NAME was also associated with better functional recovery than in controls or hypercholesterolaemic hearts. Conclusion Myocardial NO release declines rapidly during ischaemia, but increases above baseline during early reperfusion. Improved function after l-arginine treatment appears to be independent of effects upon NO release. Hypercholesterolaemia is associated with reduced myocardial NO release, under both baseline conditions and during ischaemia and reperfusion. Nitric oxide (NO) may modulate myocardial ischaemia/reperfusion (I/R) injury, but effects of hypercholesterolaemia on myocardial NO release during I/R are unknown. A NO-specific carbon fibre electrode continuously measured coronary sinus [NO] during 60 min low-flow ischaemia (1 ml/min) and 60 min free reperfusion (I/R) in isolated rabbit hearts. Experimental groups (n = 7 per group) were control, l-arginine supplement (200 μM), N-nitro-l-arginine methyl ester (L-NAME) treatment (8 μM) and hypercholesterolaemic. During early I, NO release decreased markedly in control (−1356 ± 286 pmol/min/g) and l-arginine (−1972 ± 172) groups, but less in L-NAME (−441 ± 89) and hypercholesterolaemic (−602 ± 164) groups (both p < 0.01 vs. controls). No increase in NO release during I was seen in any group. After R, NO release increased above baseline in control (+2333 ± 591 pmol/min/g) and l-arginine (+1048 ± 278) groups and hypercholesterolaemic (+1100 ± 478) (p < 0.05 vs. pre-ischaemia each group). There was little increase in NO release in the L-NAME group (+436 ± 247 pmol/min/g, p < 0.05 vs. controls). In each group, myocardial NO release declined towards pre-ischaemic levels during 60 min R. Hearts treated with l-arginine had similar NO release but better functional recovery than controls (p < 0.01). Treatment with L-NAME was also associated with better functional recovery than in controls or hypercholesterolaemic hearts. Myocardial NO release declines rapidly during ischaemia, but increases above baseline during early reperfusion. Improved function after l-arginine treatment appears to be independent of effects upon NO release. Hypercholesterolaemia is associated with reduced myocardial NO release, under both baseline conditions and during ischaemia and reperfusion." @default.
• W2031350900 created "2016-06-24" @default.
• W2031350900 creator A5029956061 @default.
• W2031350900 creator A5039795357 @default.
• W2031350900 creator A5050102953 @default.
• W2031350900 creator A5075147018 @default.
• W2031350900 date "2007-08-01" @default.
• W2031350900 modified "2023-09-29" @default.
• W2031350900 title "Myocardial Release of Nitric Oxide During Ischaemia and Reperfusion: Effects of l-Arginine and Hypercholesterolaemia" @default.
• W2031350900 cites W1934994215 @default.
• W2031350900 cites W1964972368 @default.
• W2031350900 cites W1965693429 @default.
• W2031350900 cites W1970161435 @default.
• W2031350900 cites W1978245407 @default.
• W2031350900 cites W1980805550 @default.
• W2031350900 cites W1982202040 @default.
• W2031350900 cites W1992830364 @default.
• W2031350900 cites W1997818175 @default.
• W2031350900 cites W2002879920 @default.
• W2031350900 cites W2005466083 @default.
• W2031350900 cites W2007375934 @default.
• W2031350900 cites W2008354631 @default.
• W2031350900 cites W2018598048 @default.
• W2031350900 cites W2028010937 @default.
• W2031350900 cites W2029067920 @default.
• W2031350900 cites W2029827227 @default.
• W2031350900 cites W2031016487 @default.
• W2031350900 cites W2033974115 @default.
• W2031350900 cites W2035927842 @default.
• W2031350900 cites W2037121432 @default.
• W2031350900 cites W2042656538 @default.
• W2031350900 cites W2043474235 @default.
• W2031350900 cites W2043595406 @default.
• W2031350900 cites W2044521785 @default.
• W2031350900 cites W2048164487 @default.
• W2031350900 cites W2058086138 @default.
• W2031350900 cites W2061897451 @default.
• W2031350900 cites W2078779904 @default.
• W2031350900 cites W2079380240 @default.
• W2031350900 cites W2090334375 @default.
• W2031350900 cites W2092509134 @default.
• W2031350900 cites W2092670040 @default.
• W2031350900 cites W2102749554 @default.
• W2031350900 cites W2124343254 @default.
• W2031350900 cites W2127035546 @default.
• W2031350900 cites W2135198875 @default.
• W2031350900 cites W2141211759 @default.
• W2031350900 cites W2150616706 @default.
• W2031350900 cites W2266492248 @default.
• W2031350900 cites W2327913793 @default.
• W2031350900 cites W4242786887 @default.
• W2031350900 doi "https://doi.org/10.1016/j.hlc.2007.02.092" @default.
• W2031350900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420156" @default.
• W2031350900 hasPublicationYear "2007" @default.
• W2031350900 type Work @default.
• W2031350900 sameAs 2031350900 @default.
• W2031350900 citedByCount "14" @default.
• W2031350900 countsByYear W20313509002012 @default.
• W2031350900 countsByYear W20313509002014 @default.
• W2031350900 countsByYear W20313509002015 @default.
• W2031350900 countsByYear W20313509002016 @default.
• W2031350900 countsByYear W20313509002017 @default.
• W2031350900 countsByYear W20313509002019 @default.
• W2031350900 crossrefType "journal-article" @default.
• W2031350900 hasAuthorship W2031350900A5029956061 @default.
• W2031350900 hasAuthorship W2031350900A5039795357 @default.
• W2031350900 hasAuthorship W2031350900A5050102953 @default.
• W2031350900 hasAuthorship W2031350900A5075147018 @default.
• W2031350900 hasConcept C126322002 @default.
• W2031350900 hasConcept C134018914 @default.
• W2031350900 hasConcept C164705383 @default.
• W2031350900 hasConcept C185592680 @default.
• W2031350900 hasConcept C2777468819 @default.
• W2031350900 hasConcept C42219234 @default.
• W2031350900 hasConcept C515207424 @default.
• W2031350900 hasConcept C519581460 @default.
• W2031350900 hasConcept C541997718 @default.
• W2031350900 hasConcept C55493867 @default.
• W2031350900 hasConcept C71924100 @default.
• W2031350900 hasConceptScore W2031350900C126322002 @default.
• W2031350900 hasConceptScore W2031350900C134018914 @default.
• W2031350900 hasConceptScore W2031350900C164705383 @default.
• W2031350900 hasConceptScore W2031350900C185592680 @default.
• W2031350900 hasConceptScore W2031350900C2777468819 @default.
• W2031350900 hasConceptScore W2031350900C42219234 @default.
• W2031350900 hasConceptScore W2031350900C515207424 @default.
• W2031350900 hasConceptScore W2031350900C519581460 @default.
• W2031350900 hasConceptScore W2031350900C541997718 @default.
• W2031350900 hasConceptScore W2031350900C55493867 @default.
• W2031350900 hasConceptScore W2031350900C71924100 @default.
• W2031350900 hasIssue "4" @default.
• W2031350900 hasLocation W20313509001 @default.
• W2031350900 hasLocation W20313509002 @default.
• W2031350900 hasOpenAccess W2031350900 @default.
• W2031350900 hasPrimaryLocation W20313509001 @default.
• W2031350900 hasRelatedWork W1967095436 @default.
• W2031350900 hasRelatedWork W1982094574 @default.
• W2031350900 hasRelatedWork W1988703247 @default.

• next