Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031352990> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2031352990 endingPage "1993" @default.
- W2031352990 startingPage "1983" @default.
- W2031352990 abstract "In this stability-indicating, reversed-phase high-performance liquid chromatographic method for nicardipine (NIC), forced degradation has been employed and the formed degradants were separated on a C18 (150 mm × 3.9 mm, 5 μm) analytical column using a mobile phase consisted of 70% methanol: acetic acid containing 0.01 M triethylamine with pH 4. The flow rate was 1.0 mL/min and the photodiode array detection wavelength was 353 nm. Forced degradation of the drug was carried out under acidic, basic, photolytic, and oxidative stress conditions. Chromatographic peak purity data indicated no co-eluting peaks with the main peaks. This method resulted in the detection of seven degradation products. Among these, two major degradation products from basic hydrolysis, one from oxidation by H2O2 and four from photolytic stress were identified by mass spectral data. A good linear response was achieved over the range of 0.5–40 μg/mL with a limit of detection (LOD) of 0.011 μg/mL and limit of quantification (LOQ) of 0.036 μg/mL. The suggested method was successfully applied for the analysis of NIC in its commercial capsules, with mean% recovery value of 100.11 ± 2.26%. The method was extended to the in vitro determination on NIC in spiked human plasma samples with mean% recovery of 99.04 ± 5.67%. The suggested method was utilized to investigate the kinetics of photolytic induced degradation." @default.
- W2031352990 created "2016-06-24" @default.
- W2031352990 creator A5077656836 @default.
- W2031352990 creator A5083237477 @default.
- W2031352990 date "2019-12-01" @default.
- W2031352990 modified "2023-10-01" @default.
- W2031352990 title "Stability-indicating HPLC method for the determination of nicardipine in capsules and spiked human plasma. Identification of degradation products using HPLC/MS" @default.
- W2031352990 cites W1971383439 @default.
- W2031352990 cites W1972341329 @default.
- W2031352990 cites W1976687560 @default.
- W2031352990 cites W1987391142 @default.
- W2031352990 cites W1995768569 @default.
- W2031352990 cites W2004573116 @default.
- W2031352990 cites W2007252806 @default.
- W2031352990 cites W2015412346 @default.
- W2031352990 cites W2032886187 @default.
- W2031352990 cites W2043323692 @default.
- W2031352990 cites W2059053582 @default.
- W2031352990 cites W2059659050 @default.
- W2031352990 cites W2074787136 @default.
- W2031352990 cites W2086531600 @default.
- W2031352990 cites W2087101576 @default.
- W2031352990 cites W2092642790 @default.
- W2031352990 doi "https://doi.org/10.1016/j.arabjc.2014.11.044" @default.
- W2031352990 hasPublicationYear "2019" @default.
- W2031352990 type Work @default.
- W2031352990 sameAs 2031352990 @default.
- W2031352990 citedByCount "5" @default.
- W2031352990 countsByYear W20313529902017 @default.
- W2031352990 countsByYear W20313529902019 @default.
- W2031352990 countsByYear W20313529902022 @default.
- W2031352990 countsByYear W20313529902023 @default.
- W2031352990 crossrefType "journal-article" @default.
- W2031352990 hasAuthorship W2031352990A5077656836 @default.
- W2031352990 hasAuthorship W2031352990A5083237477 @default.
- W2031352990 hasBestOaLocation W20313529901 @default.
- W2031352990 hasConcept C119128265 @default.
- W2031352990 hasConcept C178790620 @default.
- W2031352990 hasConcept C179998833 @default.
- W2031352990 hasConcept C185592680 @default.
- W2031352990 hasConcept C2776673659 @default.
- W2031352990 hasConcept C2777682752 @default.
- W2031352990 hasConcept C2779679103 @default.
- W2031352990 hasConcept C2781283055 @default.
- W2031352990 hasConcept C41008148 @default.
- W2031352990 hasConcept C43617362 @default.
- W2031352990 hasConcept C45188465 @default.
- W2031352990 hasConcept C55493867 @default.
- W2031352990 hasConcept C76155785 @default.
- W2031352990 hasConcept C94412978 @default.
- W2031352990 hasConceptScore W2031352990C119128265 @default.
- W2031352990 hasConceptScore W2031352990C178790620 @default.
- W2031352990 hasConceptScore W2031352990C179998833 @default.
- W2031352990 hasConceptScore W2031352990C185592680 @default.
- W2031352990 hasConceptScore W2031352990C2776673659 @default.
- W2031352990 hasConceptScore W2031352990C2777682752 @default.
- W2031352990 hasConceptScore W2031352990C2779679103 @default.
- W2031352990 hasConceptScore W2031352990C2781283055 @default.
- W2031352990 hasConceptScore W2031352990C41008148 @default.
- W2031352990 hasConceptScore W2031352990C43617362 @default.
- W2031352990 hasConceptScore W2031352990C45188465 @default.
- W2031352990 hasConceptScore W2031352990C55493867 @default.
- W2031352990 hasConceptScore W2031352990C76155785 @default.
- W2031352990 hasConceptScore W2031352990C94412978 @default.
- W2031352990 hasIssue "8" @default.
- W2031352990 hasLocation W20313529901 @default.
- W2031352990 hasLocation W20313529902 @default.
- W2031352990 hasOpenAccess W2031352990 @default.
- W2031352990 hasPrimaryLocation W20313529901 @default.
- W2031352990 hasRelatedWork W1964259887 @default.
- W2031352990 hasRelatedWork W1998279148 @default.
- W2031352990 hasRelatedWork W2001281989 @default.
- W2031352990 hasRelatedWork W2013299392 @default.
- W2031352990 hasRelatedWork W2030792834 @default.
- W2031352990 hasRelatedWork W2032191029 @default.
- W2031352990 hasRelatedWork W2084062459 @default.
- W2031352990 hasRelatedWork W2089660391 @default.
- W2031352990 hasRelatedWork W2155596957 @default.
- W2031352990 hasRelatedWork W2599388867 @default.
- W2031352990 hasVolume "12" @default.
- W2031352990 isParatext "false" @default.
- W2031352990 isRetracted "false" @default.
- W2031352990 magId "2031352990" @default.
- W2031352990 workType "article" @default.