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- W2031355278 abstract "Incubation of the 800 x g supernatant fluid of a human corpus luteum with 14C-pregnenolone produced progesterone. The inhibitory effects of various steroids on the production of progesterone were studied. Progesterone (Ki = 2.8 μM), 17α-hydroxy-progesterone (1.6 μM), estrone (0.24 μM) and 17β-estradiol (0.34 μM) showed mixed type inhibition on the activity of Δ5-3β-hydroxy-steroid dehydrogenase and Δ4-Δ5 isomerase (Km = 1.5 μM). Androstenedione (Ki = 3.0 μM) and testosterone (2.7 μM) also inhibited the production of progesterone, but 16α-hydroxy-progesterone was less effective (Ki = 16 μM). Among the synthetic estrogens tested, ethynylestradiol showed the highest inhibitory effect on the enzyme activity (Ki = 0.02 μM)." @default.
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- W2031355278 date "2010-05-24" @default.
- W2031355278 modified "2023-09-26" @default.
- W2031355278 title "In Vitro Effects of Steroids upon the Production of Progesterone from Pregnenolone in the Human Corpus Luteum" @default.
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- W2031355278 doi "https://doi.org/10.1111/j.1447-0756.1980.tb00500.x" @default.
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