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- W2031368755 abstract "PORCINE pancreatic islets are considered a viable source of insulin-producing tissue for the treatment of Type 1 diabetes mellitus. For this therapy to become a reality, a detailed characterization of human immune responses to porcine islets should be carried out. Our recent studies characterized the mechanism of porcine islet xenograft rejection by human CD41 T cells generated against porcine islets both by in vitro stimulation and in vivo using severe combined immunodeficient mice reconstituted with human peripheral blood leukocytes and transplanted with porcine islets. These studies concluded that a majority of human CD41 T cells recognized porcine MHC molecules as xenoantigens presented by self-antigen presenting cells (APC). To further define the mechanisms of islet xenograft rejection, we transplanted porcine islets under the kidney capsules of streptozotocin-treated C57BL/6 (BL/6), CD4 Knockout (KO), and CD8KO mice, and islet rejection was analyzed. Similarly, BL/6, CD4KO, and CD8KO mice were treated with anti-CD4 or anti-CD8 depleting monoclonal antibodies (mAb), transplanted, and monitored for rejection. To further document the role of CD41 T cells in the response to porcine islets, we studied specific T-cell proliferation to islet antigens in vitro and its requirement of APC for maximum stimulation. In addition, antibody response to porcine xenoantigens in each group of transplanted mice was measured." @default.
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- W2031368755 date "2001-02-01" @default.
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- W2031368755 title "The role of indirect antigen recognition in islet xenograft rejection" @default.
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- W2031368755 doi "https://doi.org/10.1016/s0041-1345(00)02254-5" @default.
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