FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031383224> ?p ?o ?g. }

• W2031383224 endingPage "779" @default.
• W2031383224 startingPage "769" @default.
• W2031383224 abstract "Purpose: To investigate the combined effects of interleukin-2 (IL-2) with either prostaglandin E2 (PGE2) or indomethacin (IM) on the proliferation and cytolysis of bladder tumor cells by lymphokine-activated killer (LAK) cells in patients with bladder cancer. Methods: LAK cell proliferation was assayed in the presence of various concentrations of either PGE2 or IM by cell counting. Bladder cancer cell lines BIU-87, EJ and bladder tumor cells (BTC) from the patients were cultured as target cells, and the cytotoxicity of LAK cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In addition, PGE2 in samples of conditioned medium from bladder cancer cells or peripheral blood mononuclear cells (PBMC) as well as plasma from 21 patients with bladder cancer and 20 healthy donors were determined by radioimmunoassay (RIA). Results: The proliferation of LAK cells induced by IL-2 was inhibited by PGE2 (0.05 to 5 ng/mL) in concentration-dependent manner. The enhanced growth of LAK cells was observed at certain concentrations of IM (100–400 ng/mL) from 48 to 96 h. Pretreatment of LAK cells with IM (200 ng/mL) significantly enhanced cytotoxicity against BIU-87, EJ cells, or BTC. More PGE2 was present in conditioned medium from BIU-87 cells than in the conditioned medium from PBMC. Conclusions: These studies indicate that LAK cell proliferation induced by IL-2 in patients with bladder cancer is inhibited by PGE2 produced by PBMC and bladder cancer cells. This inhibition can be overcome by IM, which may be of use in immunotherapy of bladder cancer." @default.
• W2031383224 created "2016-06-24" @default.
• W2031383224 creator A5019988055 @default.
• W2031383224 creator A5044073090 @default.
• W2031383224 creator A5044513573 @default.
• W2031383224 creator A5050294380 @default.
• W2031383224 creator A5056442083 @default.
• W2031383224 creator A5058202099 @default.
• W2031383224 creator A5086081633 @default.
• W2031383224 date "1997-11-01" @default.
• W2031383224 modified "2023-10-18" @default.
• W2031383224 title "In Vitro Effects of Prostaglandin E2 or Indomethacin on the Proliferation of Lymphokine-Activated Killer Cells and their Cytotoxicity against Bladder Tumor Cells in Patients with Bladder Cancer" @default.
• W2031383224 cites W1563827978 @default.
• W2031383224 cites W1983887692 @default.
• W2031383224 cites W1992068465 @default.
• W2031383224 cites W1992944693 @default.
• W2031383224 cites W1994675282 @default.
• W2031383224 cites W2014487380 @default.
• W2031383224 cites W2016456923 @default.
• W2031383224 cites W2024648465 @default.
• W2031383224 cites W2026191953 @default.
• W2031383224 cites W2031081545 @default.
• W2031383224 cites W2033757974 @default.
• W2031383224 cites W2038799463 @default.
• W2031383224 cites W2068467321 @default.
• W2031383224 cites W2069612743 @default.
• W2031383224 cites W2075215865 @default.
• W2031383224 cites W2075682082 @default.
• W2031383224 cites W2083698469 @default.
• W2031383224 cites W2084973713 @default.
• W2031383224 cites W2088676851 @default.
• W2031383224 cites W2131443622 @default.
• W2031383224 cites W2135124093 @default.
• W2031383224 cites W2163957129 @default.
• W2031383224 cites W2419626139 @default.
• W2031383224 cites W4239175708 @default.
• W2031383224 cites W63046270 @default.
• W2031383224 cites W2023871806 @default.
• W2031383224 doi "https://doi.org/10.1016/s0090-6980(97)00161-5" @default.
• W2031383224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9491207" @default.
• W2031383224 hasPublicationYear "1997" @default.
• W2031383224 type Work @default.
• W2031383224 sameAs 2031383224 @default.
• W2031383224 citedByCount "17" @default.
• W2031383224 countsByYear W20313832242012 @default.
• W2031383224 countsByYear W20313832242018 @default.
• W2031383224 countsByYear W20313832242020 @default.
• W2031383224 countsByYear W20313832242021 @default.
• W2031383224 crossrefType "journal-article" @default.
• W2031383224 hasAuthorship W2031383224A5019988055 @default.
• W2031383224 hasAuthorship W2031383224A5044073090 @default.
• W2031383224 hasAuthorship W2031383224A5044513573 @default.
• W2031383224 hasAuthorship W2031383224A5050294380 @default.
• W2031383224 hasAuthorship W2031383224A5056442083 @default.
• W2031383224 hasAuthorship W2031383224A5058202099 @default.
• W2031383224 hasAuthorship W2031383224A5086081633 @default.
• W2031383224 hasConcept C109316439 @default.
• W2031383224 hasConcept C121608353 @default.
• W2031383224 hasConcept C126322002 @default.
• W2031383224 hasConcept C137061746 @default.
• W2031383224 hasConcept C149532602 @default.
• W2031383224 hasConcept C154317977 @default.
• W2031383224 hasConcept C185592680 @default.
• W2031383224 hasConcept C202751555 @default.
• W2031383224 hasConcept C203014093 @default.
• W2031383224 hasConcept C2777198256 @default.
• W2031383224 hasConcept C2777371288 @default.
• W2031383224 hasConcept C2777956040 @default.
• W2031383224 hasConcept C2778690821 @default.
• W2031383224 hasConcept C2780352672 @default.
• W2031383224 hasConcept C28651165 @default.
• W2031383224 hasConcept C49382859 @default.
• W2031383224 hasConcept C502942594 @default.
• W2031383224 hasConcept C54355233 @default.
• W2031383224 hasConcept C55493867 @default.
• W2031383224 hasConcept C62112901 @default.
• W2031383224 hasConcept C71924100 @default.
• W2031383224 hasConcept C73588182 @default.
• W2031383224 hasConcept C81885089 @default.
• W2031383224 hasConcept C86803240 @default.
• W2031383224 hasConcept C96232424 @default.
• W2031383224 hasConceptScore W2031383224C109316439 @default.
• W2031383224 hasConceptScore W2031383224C121608353 @default.
• W2031383224 hasConceptScore W2031383224C126322002 @default.
• W2031383224 hasConceptScore W2031383224C137061746 @default.
• W2031383224 hasConceptScore W2031383224C149532602 @default.
• W2031383224 hasConceptScore W2031383224C154317977 @default.
• W2031383224 hasConceptScore W2031383224C185592680 @default.
• W2031383224 hasConceptScore W2031383224C202751555 @default.
• W2031383224 hasConceptScore W2031383224C203014093 @default.
• W2031383224 hasConceptScore W2031383224C2777198256 @default.
• W2031383224 hasConceptScore W2031383224C2777371288 @default.
• W2031383224 hasConceptScore W2031383224C2777956040 @default.
• W2031383224 hasConceptScore W2031383224C2778690821 @default.
• W2031383224 hasConceptScore W2031383224C2780352672 @default.
• W2031383224 hasConceptScore W2031383224C28651165 @default.
• W2031383224 hasConceptScore W2031383224C49382859 @default.
• W2031383224 hasConceptScore W2031383224C502942594 @default.

• next