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• W2031402842 abstract "Abstract Background and Aim: In Western countries, polymorphism of pro‐inflammatory cytokine genes is associated with the development of gastric cancer and duodenal ulcer. The aim of this study was to clarify the association of polymorphisms of interleukin ( IL ) ‐1β and tumor necrosis factor ( TNF ) ‐α with susceptibility to peptic ulcer diseases and gastric cancer in Japan. Methods: The IL‐1β ‐511/‐31 and TNF‐α ‐308/‐857/‐863/‐1031 genotypes were determined in Helicobacter pylori ‐positive patients with gastritis only ( n = 164), gastric ulcers ( n = 110), duodenal ulcers ( n = 94), or gastric cancers ( n = 105), and in H. pylori ‐negative controls ( n = 172). Results: Carriage of the alleles TNF‐α‐ 857 T (odd ratio [OR], 1.826; 95% confidence interval [CI], 1.097–3.039), TNF‐α‐ 863 A (OR, 1.788; 95% CI, 1.079–2.905) and TNF‐α ‐1031 C (OR, 1.912; 95% CI, 1.152–3.171) was associated with increased risk for gastric ulcer development. Carriage of the alleles TNF‐α‐ 857 T (OR, 1.686; 95% CI, 1.003–2.832), TNF‐α‐ 863 A (OR, 1.863; 95% CI, 1.118–3.107) and TNF‐α ‐1031 C (OR 2.074; 95% CI, 1.244–3.457) was also associated with increased risk of gastric cancer development. There was no relationship between the development of H. pylori ‐related diseases and polymorphisms of IL‐1β ‐511/‐31 and TNF‐α ‐308. The simultaneous carriage of three different high‐producer alleles of TNF‐α ‐857/‐863/‐1031 significantly increased the risk of gastric ulcer (OR, 6.57; 95% CI, 2.34–18.40) and gastric cancer (OR, 5.20; 95% CI, 1.83–14.78). Conclusions: Polymorphisms in TNF‐α rather than IL‐1β are associated with increased risk for gastric ulcers and gastric cancer in Japan. The simultaneous carriage of more than one high‐producer allele of TNF‐α further increased the risks for gastric ulcer and cancer." @default.
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• W2031402842 date "2006-12-15" @default.
• W2031402842 modified "2023-10-10" @default.
• W2031402842 title "Different effects of polymorphisms of tumor necrosis factor-alpha and interleukin-1 beta on development of peptic ulcer and gastric cancer" @default.
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• W2031402842 doi "https://doi.org/10.1111/j.1440-1746.2006.04442.x" @default.
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