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- W2031402849 endingPage "8868" @default.
- W2031402849 startingPage "8868" @default.
- W2031402849 abstract "The current paradigm in the amyloid hypothesis brands small β-amyloid (Aβ) oligomers as the toxic species in Alzheimer's disease (AD). These oligomers are fibril-like; contain β-sheet structure, and present exposed hydrophobic surface. Oligomers with this motif are capable of penetrating the cell membrane, gathering to form toxic ion channels. Current agents suppressing precursor Aβ cleavage have only met partial success; and to date, those targeting the peptides and their assemblies in the aqueous environment of the extracellular space largely fail in clinical trials. One possible reason is failure to reach membrane-embedded targets of disease-‘infected’ cells. Here we provide an overview, point to the need to account for the lipid environment when aiming to prevent the formation of toxic channels, and propose a combination therapy to target the species spectrum." @default.
- W2031402849 created "2016-06-24" @default.
- W2031402849 creator A5006553652 @default.
- W2031402849 creator A5010601422 @default.
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- W2031402849 creator A5031961391 @default.
- W2031402849 creator A5053680960 @default.
- W2031402849 creator A5071084031 @default.
- W2031402849 date "2013-01-01" @default.
- W2031402849 modified "2023-10-18" @default.
- W2031402849 title "Alzheimer's disease: which type of amyloid-preventing drug agents to employ?" @default.
- W2031402849 cites W139300322 @default.
- W2031402849 cites W1531666134 @default.
- W2031402849 cites W1560950394 @default.
- W2031402849 cites W1584032701 @default.
- W2031402849 cites W1586874910 @default.
- W2031402849 cites W1620179564 @default.
- W2031402849 cites W1816679421 @default.
- W2031402849 cites W1911110924 @default.
- W2031402849 cites W192124582 @default.
- W2031402849 cites W1960543132 @default.
- W2031402849 cites W1964978234 @default.
- W2031402849 cites W1966361951 @default.
- W2031402849 cites W1967913555 @default.
- W2031402849 cites W1968041782 @default.
- W2031402849 cites W1968900405 @default.
- W2031402849 cites W1969553345 @default.
- W2031402849 cites W1976544813 @default.
- W2031402849 cites W1976602187 @default.
- W2031402849 cites W1978918572 @default.
- W2031402849 cites W1981458288 @default.
- W2031402849 cites W1983367752 @default.
- W2031402849 cites W1983668432 @default.
- W2031402849 cites W1987469323 @default.
- W2031402849 cites W1987503846 @default.
- W2031402849 cites W1989574240 @default.
- W2031402849 cites W1989810100 @default.
- W2031402849 cites W1989948422 @default.
- W2031402849 cites W1991241547 @default.
- W2031402849 cites W1991329153 @default.
- W2031402849 cites W1991388423 @default.
- W2031402849 cites W1991993391 @default.
- W2031402849 cites W1992989385 @default.
- W2031402849 cites W1993465897 @default.
- W2031402849 cites W1994232621 @default.
- W2031402849 cites W1994398814 @default.
- W2031402849 cites W1994726986 @default.
- W2031402849 cites W1997170675 @default.
- W2031402849 cites W1999007957 @default.
- W2031402849 cites W2001751866 @default.
- W2031402849 cites W2001830061 @default.
- W2031402849 cites W2005460596 @default.
- W2031402849 cites W2009157533 @default.
- W2031402849 cites W2009393818 @default.
- W2031402849 cites W2011523681 @default.
- W2031402849 cites W2014451295 @default.
- W2031402849 cites W2016698723 @default.
- W2031402849 cites W2022756726 @default.
- W2031402849 cites W2023528214 @default.
- W2031402849 cites W2026981923 @default.
- W2031402849 cites W2028872675 @default.
- W2031402849 cites W2029181535 @default.
- W2031402849 cites W2051044968 @default.
- W2031402849 cites W2051609969 @default.
- W2031402849 cites W2053665966 @default.
- W2031402849 cites W2057871179 @default.
- W2031402849 cites W2058368188 @default.
- W2031402849 cites W2060210385 @default.
- W2031402849 cites W2060914703 @default.
- W2031402849 cites W2061531041 @default.
- W2031402849 cites W2062990728 @default.
- W2031402849 cites W2063679630 @default.
- W2031402849 cites W2070004512 @default.
- W2031402849 cites W2073686561 @default.
- W2031402849 cites W2074619433 @default.
- W2031402849 cites W2075481535 @default.
- W2031402849 cites W2075930760 @default.
- W2031402849 cites W2076063919 @default.
- W2031402849 cites W2079749054 @default.
- W2031402849 cites W2080100823 @default.
- W2031402849 cites W2080507537 @default.
- W2031402849 cites W2080821312 @default.
- W2031402849 cites W2081881251 @default.
- W2031402849 cites W2082038580 @default.
- W2031402849 cites W2084972185 @default.
- W2031402849 cites W2087861584 @default.
- W2031402849 cites W2090496922 @default.
- W2031402849 cites W2091514612 @default.
- W2031402849 cites W2093344681 @default.
- W2031402849 cites W2093861673 @default.
- W2031402849 cites W2095674336 @default.
- W2031402849 cites W2096336861 @default.
- W2031402849 cites W2099174404 @default.
- W2031402849 cites W2100817247 @default.
- W2031402849 cites W2102510966 @default.
- W2031402849 cites W2105197721 @default.
- W2031402849 cites W2105949921 @default.