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- W2031406807 abstract "Amantadine-induced tremor has been investigated using mice. Experiments with, mebanazine, reserpine, diethyl-dithiocarbamate, and p-chlorophenylalanie suggest that the tremorgenic action of amantadine is influenced by a balance between three putative central nervous system (CNS) transmitters: noradrenaline, dopamine and 5-hydroxytryptamine (5-HT). Drugs which reduce the concentration of the catecholamines in brain increase amantadine-induced tremor. p-Chlorophenylalanine, which specifically depletes brain 5-HT, antagonises amantadine-induced tremor. An ED50 (tremor) dose of amantadine decreases the concentration of 5-hydroxyindoleacetic acid (5-HIAA) in rat brain, particularly when this is elevated due to pretreatment with 5-hydroxytryptophan. Neither inhibition of monoamine oxidase nor reduction of 5-HT-reuptake appear to be responsible for this decrease. Experiments on rat fundus suggest that amantadine increased the sensitivity of receptors to 5-HT. A similar mechanism of action in the CNS could explain both the tremor and the decrease in brain 5-HIAA. The possible relevance of these findings is discussed with respect to the known anti-Parkinson action of amantadine." @default.
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- W2031406807 title "Amantadine tremor, a 5-hydroxytryptamine-mediated response?" @default.
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- W2031406807 doi "https://doi.org/10.1016/0014-2999(75)90119-3" @default.
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