FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031421957> ?p ?o ?g. }

• W2031421957 endingPage "525" @default.
• W2031421957 startingPage "516" @default.
• W2031421957 abstract "Objectives: The expression of human γ globin is developmentally regulated through mechanisms that affect the transcriptional activity of its encoding gene. The current manuscript investigates whether the efficiency of this process might be enhanced though an unrecognized post-transcriptional event that defines the stability of γ-globin mRNA. Methods: Experiments were conducted in vivo in transgenic mice expressing human γ globin in their adult erythroid cells. The expression of γ-globin protein was manipulated by breeding the transgene into animals producing different levels of endogenous mouse β-globin. Changes in the expression of γ globin were then correlated to measures of γ-globin mRNA stability in vivo. Results: Human γ globin was expressed at higher levels in thalassemic than in than non-thalassemic control transgenics, paralleling a highly significant increase in the stability of γ-globin mRNA. Other molecular events–including possible transcriptional induction of the transgene, or an increase in the stability of the γ-globin protein–did not appear to contribute to the observed increase in transgene expression. As anticipated, the stability of γ-globin mRNA also fell in bitransgenic animals that co-expressed human β-globin mRNA. Conclusions: Our results are consistent with a model for dynamic post-transcriptional control of γ-globin gene expression, through modulation of the stability of its encoding mRNA. Moreover, the stability of γ-globin mRNA appears to be inversely related to ambient levels of co-expressed β-globin mRNA. This data suggests that therapeutic gene-reactivation and/or gene-replacement therapies may be particularly effective in individuals with severe forms of β-thalassemia." @default.
• W2031421957 created "2016-06-24" @default.
• W2031421957 creator A5068048939 @default.
• W2031421957 date "2007-12-01" @default.
• W2031421957 modified "2023-09-27" @default.
• W2031421957 title "A post-transcriptional process contributes to efficient γ-globin gene silencing in definitive erythroid cells" @default.
• W2031421957 cites W126732268 @default.
• W2031421957 cites W1494573427 @default.
• W2031421957 cites W1838293083 @default.
• W2031421957 cites W1862820015 @default.
• W2031421957 cites W1883598582 @default.
• W2031421957 cites W1899577620 @default.
• W2031421957 cites W1963874550 @default.
• W2031421957 cites W1966075932 @default.
• W2031421957 cites W1973273611 @default.
• W2031421957 cites W1989277884 @default.
• W2031421957 cites W1990407013 @default.
• W2031421957 cites W1993532214 @default.
• W2031421957 cites W1997954158 @default.
• W2031421957 cites W1999749379 @default.
• W2031421957 cites W2003240678 @default.
• W2031421957 cites W2004787421 @default.
• W2031421957 cites W2007594092 @default.
• W2031421957 cites W2016181550 @default.
• W2031421957 cites W2044346067 @default.
• W2031421957 cites W2046184465 @default.
• W2031421957 cites W2049271350 @default.
• W2031421957 cites W2050206304 @default.
• W2031421957 cites W2057582400 @default.
• W2031421957 cites W2064724683 @default.
• W2031421957 cites W2065637733 @default.
• W2031421957 cites W2075685244 @default.
• W2031421957 cites W2081045659 @default.
• W2031421957 cites W2084461619 @default.
• W2031421957 cites W2085631191 @default.
• W2031421957 cites W2091399084 @default.
• W2031421957 cites W2091513425 @default.
• W2031421957 cites W2100018747 @default.
• W2031421957 cites W2104432183 @default.
• W2031421957 cites W2105568806 @default.
• W2031421957 cites W2114130204 @default.
• W2031421957 cites W2114231411 @default.
• W2031421957 cites W2115018128 @default.
• W2031421957 cites W2158537780 @default.
• W2031421957 cites W2165411433 @default.
• W2031421957 cites W2170877733 @default.
• W2031421957 cites W2419968394 @default.
• W2031421957 cites W243791724 @default.
• W2031421957 cites W4231329082 @default.
• W2031421957 cites W4231481431 @default.
• W2031421957 cites W4235713981 @default.
• W2031421957 cites W95169970 @default.
• W2031421957 doi "https://doi.org/10.1111/j.1600-0609.2007.00970.x" @default.
• W2031421957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17976188" @default.
• W2031421957 hasPublicationYear "2007" @default.
• W2031421957 type Work @default.
• W2031421957 sameAs 2031421957 @default.
• W2031421957 citedByCount "12" @default.
• W2031421957 countsByYear W20314219572013 @default.
• W2031421957 countsByYear W20314219572014 @default.
• W2031421957 countsByYear W20314219572018 @default.
• W2031421957 countsByYear W20314219572019 @default.
• W2031421957 countsByYear W20314219572020 @default.
• W2031421957 crossrefType "journal-article" @default.
• W2031421957 hasAuthorship W2031421957A5068048939 @default.
• W2031421957 hasConcept C102230213 @default.
• W2031421957 hasConcept C104317684 @default.
• W2031421957 hasConcept C105580179 @default.
• W2031421957 hasConcept C119056186 @default.
• W2031421957 hasConcept C125996951 @default.
• W2031421957 hasConcept C150194340 @default.
• W2031421957 hasConcept C153911025 @default.
• W2031421957 hasConcept C165864922 @default.
• W2031421957 hasConcept C54355233 @default.
• W2031421957 hasConcept C86803240 @default.
• W2031421957 hasConcept C95444343 @default.
• W2031421957 hasConceptScore W2031421957C102230213 @default.
• W2031421957 hasConceptScore W2031421957C104317684 @default.
• W2031421957 hasConceptScore W2031421957C105580179 @default.
• W2031421957 hasConceptScore W2031421957C119056186 @default.
• W2031421957 hasConceptScore W2031421957C125996951 @default.
• W2031421957 hasConceptScore W2031421957C150194340 @default.
• W2031421957 hasConceptScore W2031421957C153911025 @default.
• W2031421957 hasConceptScore W2031421957C165864922 @default.
• W2031421957 hasConceptScore W2031421957C54355233 @default.
• W2031421957 hasConceptScore W2031421957C86803240 @default.
• W2031421957 hasConceptScore W2031421957C95444343 @default.
• W2031421957 hasIssue "6" @default.
• W2031421957 hasLocation W20314219571 @default.
• W2031421957 hasLocation W20314219572 @default.
• W2031421957 hasOpenAccess W2031421957 @default.
• W2031421957 hasPrimaryLocation W20314219571 @default.
• W2031421957 hasRelatedWork W146736245 @default.
• W2031421957 hasRelatedWork W1985767170 @default.
• W2031421957 hasRelatedWork W2158875536 @default.
• W2031421957 hasRelatedWork W2162085217 @default.
• W2031421957 hasRelatedWork W2383286439 @default.
• W2031421957 hasRelatedWork W2393232383 @default.

• next