Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031424368> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2031424368 endingPage "259" @default.
- W2031424368 startingPage "258" @default.
- W2031424368 abstract "The polyclonal activator pokeweed mitogen (PWM) has been widely used to study regulatory mechanisms in the differentiation of human B cells into immunoglobulin (Ig) secreting plasma cells (for review see Ref. 1). PWM-induced proliferation and differentiation of human B cells is strictly T-cell dependent and may provide a means to study the immunoregulatory activities of T-cell subsets(1-3). Furthermore, several antigen-non-specific T-cell derived factors have been shown toregulate B-cell activation(4,5). One class ofsolublefactors, designatedB-cellgrowthfactors(BCGF), supports growth of human B cells, when pre-activated by anti-Ig antibody or Staphylococcus aureus Cowan strain I(SAC)(4,5). A second class offactors, B-cell differentiation factors (BCDF) induces terminal differentiation of activated B cells into Ig secretingplasma cells(5). Here Frank Miedema and Cornelius Melief examine the claims and counterclaims concerning the influence of interleukin 2, a T-cell growth factor, on B cells and conclude that interleukin 2 has a pivotal role in the humoral immune response. The role of Interleukin-2 (IL-2) in B-cell activation is still controversial. Although a direct effect of IL-2 on resting murine B cells has been suggested by some investigators(6,7), others claim that IL-2 did not act on resting murine B cells(8-10)." @default.
- W2031424368 created "2016-06-24" @default.
- W2031424368 creator A5042340711 @default.
- W2031424368 creator A5069161180 @default.
- W2031424368 date "1985-09-01" @default.
- W2031424368 modified "2023-10-16" @default.
- W2031424368 title "T-cell regulation of human B-cell activation. A reappraisal of the role of interleukin 2" @default.
- W2031424368 cites W1493800755 @default.
- W2031424368 cites W1503659276 @default.
- W2031424368 cites W1514577273 @default.
- W2031424368 cites W1560071173 @default.
- W2031424368 cites W1571911874 @default.
- W2031424368 cites W1917147955 @default.
- W2031424368 cites W1931900796 @default.
- W2031424368 cites W1986004077 @default.
- W2031424368 cites W1989671244 @default.
- W2031424368 cites W2001013873 @default.
- W2031424368 cites W2004654501 @default.
- W2031424368 cites W2012348028 @default.
- W2031424368 cites W201659892 @default.
- W2031424368 cites W2038040665 @default.
- W2031424368 cites W2065961289 @default.
- W2031424368 cites W2067475593 @default.
- W2031424368 cites W2097788092 @default.
- W2031424368 cites W2104196887 @default.
- W2031424368 cites W2115184661 @default.
- W2031424368 cites W2138424708 @default.
- W2031424368 cites W2145498103 @default.
- W2031424368 cites W2150988478 @default.
- W2031424368 cites W2165349231 @default.
- W2031424368 doi "https://doi.org/10.1016/0167-5699(85)90061-1" @default.
- W2031424368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25290563" @default.
- W2031424368 hasPublicationYear "1985" @default.
- W2031424368 type Work @default.
- W2031424368 sameAs 2031424368 @default.
- W2031424368 citedByCount "22" @default.
- W2031424368 crossrefType "journal-article" @default.
- W2031424368 hasAuthorship W2031424368A5042340711 @default.
- W2031424368 hasAuthorship W2031424368A5069161180 @default.
- W2031424368 hasConcept C137061746 @default.
- W2031424368 hasConcept C141440757 @default.
- W2031424368 hasConcept C145558887 @default.
- W2031424368 hasConcept C153911025 @default.
- W2031424368 hasConcept C157695867 @default.
- W2031424368 hasConcept C159654299 @default.
- W2031424368 hasConcept C200180986 @default.
- W2031424368 hasConcept C202751555 @default.
- W2031424368 hasConcept C203014093 @default.
- W2031424368 hasConcept C2776090121 @default.
- W2031424368 hasConcept C2778453870 @default.
- W2031424368 hasConcept C2781005381 @default.
- W2031424368 hasConcept C54355233 @default.
- W2031424368 hasConcept C67662055 @default.
- W2031424368 hasConcept C86803240 @default.
- W2031424368 hasConcept C8891405 @default.
- W2031424368 hasConcept C95444343 @default.
- W2031424368 hasConcept C956191 @default.
- W2031424368 hasConceptScore W2031424368C137061746 @default.
- W2031424368 hasConceptScore W2031424368C141440757 @default.
- W2031424368 hasConceptScore W2031424368C145558887 @default.
- W2031424368 hasConceptScore W2031424368C153911025 @default.
- W2031424368 hasConceptScore W2031424368C157695867 @default.
- W2031424368 hasConceptScore W2031424368C159654299 @default.
- W2031424368 hasConceptScore W2031424368C200180986 @default.
- W2031424368 hasConceptScore W2031424368C202751555 @default.
- W2031424368 hasConceptScore W2031424368C203014093 @default.
- W2031424368 hasConceptScore W2031424368C2776090121 @default.
- W2031424368 hasConceptScore W2031424368C2778453870 @default.
- W2031424368 hasConceptScore W2031424368C2781005381 @default.
- W2031424368 hasConceptScore W2031424368C54355233 @default.
- W2031424368 hasConceptScore W2031424368C67662055 @default.
- W2031424368 hasConceptScore W2031424368C86803240 @default.
- W2031424368 hasConceptScore W2031424368C8891405 @default.
- W2031424368 hasConceptScore W2031424368C95444343 @default.
- W2031424368 hasConceptScore W2031424368C956191 @default.
- W2031424368 hasIssue "9" @default.
- W2031424368 hasLocation W20314243681 @default.
- W2031424368 hasLocation W20314243682 @default.
- W2031424368 hasOpenAccess W2031424368 @default.
- W2031424368 hasPrimaryLocation W20314243681 @default.
- W2031424368 hasRelatedWork W1161275149 @default.
- W2031424368 hasRelatedWork W1204472489 @default.
- W2031424368 hasRelatedWork W151979045 @default.
- W2031424368 hasRelatedWork W1525444012 @default.
- W2031424368 hasRelatedWork W1903855848 @default.
- W2031424368 hasRelatedWork W1980061078 @default.
- W2031424368 hasRelatedWork W2002984025 @default.
- W2031424368 hasRelatedWork W2024501042 @default.
- W2031424368 hasRelatedWork W2079988118 @default.
- W2031424368 hasRelatedWork W2092907342 @default.
- W2031424368 hasVolume "6" @default.
- W2031424368 isParatext "false" @default.
- W2031424368 isRetracted "false" @default.
- W2031424368 magId "2031424368" @default.
- W2031424368 workType "article" @default.