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• W2031432431 abstract "Evidence is accumulating suggesting that platelet-activating factor plays a role in inflammatory dermatoses. Mass spectrometric methods were used to examine the molecular species of sn-2 acetyl glycerophosphocholines (GPC) synthesized by primary cultures of human neonatal foreskin-derived keratinocytes. Ionophore-stimulated keratinocytes synthesize both 1-alkyl and 1-acyl sn-2 acetyl-GPC, and the relative amounts were as follows: hexadecyl > palmitoyl > octadecyl > stearoyl at the sn-1 position. PAF synthesis in the keratinocyte-derived cell line HaCaT was inhibited by dexamethasone, suggesting that the anti-inflammatory effects of glucocorticosteroids in inflammatory dermatoses might be in part related to the inhibition of the synthesis of mediators such as PAF." @default.
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• W2031432431 date "1997-07-01" @default.
• W2031432431 modified "2023-09-25" @default.
• W2031432431 title "Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes" @default.
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• W2031432431 doi "https://doi.org/10.1016/s0929-7855(97)00575-0" @default.
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