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• W2031432627 endingPage "19" @default.
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• W2031432627 abstract "Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis Masahiko Mihara1, Yoshiyuki Ohsugi2, Tadamitsu Kishimoto31Product Research Department, Chugai Pharmaceutical Co Ltd, Fuji-Gotemba Research Laboratories, Shizuoka, Japan; 2Chugai Pharmaceutical Co Ltd, Tokyo, Japan; 3Laboratory of Immunoregulation, Graduate School of Frontier Biosciences, Osaka University, Osaka, JapanAbstract: Interleukin (IL)-6 has a variety of biological functions. For example, it stimulates the production of acute-phase reactants (C-reactive protein and serum amyloid A) and hepcidin which interferes with iron recycling and absorption, causing iron-deficient anemia, and augments expression of vascular endothelial growth factor and receptor activator of nuclear factor-κB ligand in synovial cells, leading to neovascularization and osteoclast formation. IL-6 also acts on lymphocytes, not only on B cells to stimulate autoantibody production, but also on naïve T helper cells to promote Th17 cell differentiation. Thus, an imbalance between T cell subsets possibly contributes to development of rheumatoid arthritis. Several clinical studies have demonstrated that a humanized anti-IL-6 receptor antibody, tocilizumab, improves clinical symptoms in rheumatoid arthritis. Tocilizumab prevented radiographic progression of joint destruction by inhibiting cartilage/bone resorption. Tocilizumab also improved hematological abnormalities, including hypergammaglobulinemia, high levels of autoantibodies, and elevation of erythrocyte sedimentation rate and acute-phase proteins. Importantly, tocilizumab improved quality of life by reducing systemic symptoms, including fatigue, anemia, anorexia, and fever. These findings have confirmed that hyperproduction of IL-6 is responsible for the above clinical symptoms, including joint destruction. Many patients treated with tocilizumab achieved clinical remission associated with decreased serum IL-6, suggesting that IL-6 enhances autoimmunity. Tocilizumab is a new therapeutic option for rheumatoid arthritis.Keywords: interleukin-6, tocilizumab, efficacy, safety, mode of action" @default.
• W2031432627 created "2016-06-24" @default.
• W2031432627 creator A5021463605 @default.
• W2031432627 creator A5035512198 @default.
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• W2031432627 date "2011-02-01" @default.
• W2031432627 modified "2023-09-26" @default.
• W2031432627 title "Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis" @default.
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• W2031432627 doi "https://doi.org/10.2147/oarrr.s17118" @default.
• W2031432627 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5074778" @default.
• W2031432627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27790001" @default.
• W2031432627 hasPublicationYear "2011" @default.
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