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• W2031433414 abstract "To understand the biologic and clinical importance of intratumoral natural killer cells CD16+CD56+CD3 and NKT CD16+CD56+CD3 cells in immune surveillance against cervical cancer. To understand the significance of NK (CD16+CD56+CD3-) and NKT (CD16+CD56+CD3-) in immune surveillance against cervical cancer, we analysed 39 peripheral blood and 30 biopsy samples from cervical cancer patients, and 40 peripheral blood and 5 biopsy samples from healthy women with normal cytology. The frequencies of NK and NKT and HLA-I expression in keratinocytes were analysed by flow cytometry. In peripheral blood, a higher frequency of NK was observed in the patient group compared with the controls (p = 0.002). However, this increase was not reflected in TILs (p = 0,095). A significant reduction of HLA-I expression was observed in the patient group compared to the control group (p = 0.019). A low number of NK infiltrated was observed in tumors of patients with HLA-I down regulation, but it was not significant (p=0.374). A low number of NK infiltration was associated with shorter survival, but it was not significant (p = 0.275). Our results show that although in peripheral blood an increase in NK population was observed in patient group, this increase was not reflected in TILs. It is possible that this inefficient migration of NK's into the tumor milieu could be related to the expression of immunosuppressive cytokines, in particular IL-10. Entender la importancia biológica y clínica de las células intratumorales natural killer (NK) CD16+CD56+CD3- y de las células natural killer T (NKT) CD16+CD56+CD3- en la inmunovigilancia del cáncer de cuello uterino (CCU). Para comprender el papel de las NK (CD16+CD56+CD3-) y de las células natural killer T (NKT) (CD16+CD56+CD3-) en la inmunovigilancia del CCU, se analizaron 39 muestras de sangre periférica (SP) y 30 biopsias de pacientes con CCU, así como de 40 muestras de SP y 5 biopsias de cuello uterino de mujeres con citología normal. Las frecuencias de NK y NKT y la expresión de HLA-I se analizaron por citometría de flujo. Se observó una mayor frecuencia de NK en SP en el grupo de pacientes comparado con el grupo control (p = 0,002). Sin embargo, este aumento no se reflejó en TIL (p = 0,095). Una reducción significativa de HLA-I se observó en el grupo de pacientes (p = 0,019). Esta disminución se asoció una disminución en el número de NK, pero no fue significativa (p = 0,374). Un bajo número de NK se asoció con una menor supervivencia, pero no fue significativo (p = 0,275). Nuestros resultados muestran que aunque en SP se observa un incremento de NK, este no se refleja en los TIL. Es posible que este tráfico ineficiente de células NK hacia el tumor esté alterado por la expresión de citoquinas inmunosupresoras, en particular IL-10." @default.
• W2031433414 created "2016-06-24" @default.
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• W2031433414 date "2012-01-01" @default.
• W2031433414 modified "2023-10-14" @default.
• W2031433414 title "Analysis of NK Cells in Peripheral Blood and Tumor Infiltrating Lymphocytes in Cervical Cancer Patients" @default.
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• W2031433414 doi "https://doi.org/10.1016/s0123-9015(12)70027-6" @default.
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