FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031438670> ?p ?o ?g. }

• W2031438670 endingPage "e59443" @default.
• W2031438670 startingPage "e59443" @default.
• W2031438670 abstract "Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be prognostic of diabetes. To understand the mechanisms whereby obesity affects BCAAs and protein metabolism, we employed metabolomics and measured rates of [1-(14)C]-leucine metabolism, tissue-specific protein synthesis and branched-chain keto-acid (BCKA) dehydrogenase complex (BCKDC) activities. Male obese Zucker rats (11-weeks old) had increased body weight (BW, 53%), liver (107%) and fat (∼300%), but lower plantaris and gastrocnemius masses (-21-24%). Plasma BCAAs and BCKAs were elevated 45-69% and ∼100%, respectively, in obese rats. Processes facilitating these rises appeared to include increased dietary intake (23%), leucine (Leu) turnover and proteolysis [35% per g fat free mass (FFM), urinary markers of proteolysis: 3-methylhistidine (183%) and 4-hydroxyproline (766%)] and decreased BCKDC per g kidney, heart, gastrocnemius and liver (-47-66%). A process disposing of circulating BCAAs, protein synthesis, was increased 23-29% by obesity in whole-body (FFM corrected), gastrocnemius and liver. Despite the observed decreases in BCKDC activities per gm tissue, rates of whole-body Leu oxidation in obese rats were 22% and 59% higher normalized to BW and FFM, respectively. Consistently, urinary concentrations of eight BCAA catabolism-derived acylcarnitines were also elevated. The unexpected increase in BCAA oxidation may be due to a substrate effect in liver. Supporting this idea, BCKAs were elevated more in liver (193-418%) than plasma or muscle, and per g losses of hepatic BCKDC activities were completely offset by increased liver mass, in contrast to other tissues. In summary, our results indicate that plasma BCKAs may represent a more sensitive metabolic signature for obesity than BCAAs. Processes supporting elevated BCAA]BCKAs in the obese Zucker rat include increased dietary intake, Leu and protein turnover along with impaired BCKDC activity. Elevated BCAAs/BCKAs may contribute to observed elevations in protein synthesis and BCAA oxidation." @default.
• W2031438670 created "2016-06-24" @default.
• W2031438670 creator A5002684663 @default.
• W2031438670 creator A5027590215 @default.
• W2031438670 creator A5029460450 @default.
• W2031438670 creator A5042437739 @default.
• W2031438670 creator A5042878583 @default.
• W2031438670 creator A5048304741 @default.
• W2031438670 creator A5048971230 @default.
• W2031438670 creator A5061461109 @default.
• W2031438670 creator A5063050485 @default.
• W2031438670 creator A5064095780 @default.
• W2031438670 creator A5073807348 @default.
• W2031438670 creator A5090325884 @default.
• W2031438670 date "2013-03-20" @default.
• W2031438670 modified "2023-10-15" @default.
• W2031438670 title "Leucine and Protein Metabolism in Obese Zucker Rats" @default.
• W2031438670 cites W113705058 @default.
• W2031438670 cites W148155436 @default.
• W2031438670 cites W1495487817 @default.
• W2031438670 cites W1498052402 @default.
• W2031438670 cites W1533557828 @default.
• W2031438670 cites W1762836351 @default.
• W2031438670 cites W1823899023 @default.
• W2031438670 cites W1864235669 @default.
• W2031438670 cites W1883642995 @default.
• W2031438670 cites W1908039135 @default.
• W2031438670 cites W1946555313 @default.
• W2031438670 cites W1963756943 @default.
• W2031438670 cites W1964119349 @default.
• W2031438670 cites W1978072893 @default.
• W2031438670 cites W1979227002 @default.
• W2031438670 cites W1979772514 @default.
• W2031438670 cites W1980811143 @default.
• W2031438670 cites W1995187187 @default.
• W2031438670 cites W2005875533 @default.
• W2031438670 cites W2006092619 @default.
• W2031438670 cites W2014671368 @default.
• W2031438670 cites W2016253969 @default.
• W2031438670 cites W2017771330 @default.
• W2031438670 cites W2021246671 @default.
• W2031438670 cites W2022138763 @default.
• W2031438670 cites W2023422602 @default.
• W2031438670 cites W2028151674 @default.
• W2031438670 cites W2036720248 @default.
• W2031438670 cites W2042316825 @default.
• W2031438670 cites W2042624513 @default.
• W2031438670 cites W2044544963 @default.
• W2031438670 cites W2046557171 @default.
• W2031438670 cites W2048236996 @default.
• W2031438670 cites W2050153048 @default.
• W2031438670 cites W2050162616 @default.
• W2031438670 cites W2058163281 @default.
• W2031438670 cites W2058825988 @default.
• W2031438670 cites W2063554500 @default.
• W2031438670 cites W2064592496 @default.
• W2031438670 cites W2066772455 @default.
• W2031438670 cites W2067152194 @default.
• W2031438670 cites W2068256216 @default.
• W2031438670 cites W2071891347 @default.
• W2031438670 cites W2076254572 @default.
• W2031438670 cites W2078518439 @default.
• W2031438670 cites W2079664351 @default.
• W2031438670 cites W2082085648 @default.
• W2031438670 cites W2089076031 @default.
• W2031438670 cites W2089663037 @default.
• W2031438670 cites W2091990362 @default.
• W2031438670 cites W2092903706 @default.
• W2031438670 cites W2099623630 @default.
• W2031438670 cites W2099675749 @default.
• W2031438670 cites W2100565159 @default.
• W2031438670 cites W2106060647 @default.
• W2031438670 cites W2107674876 @default.
• W2031438670 cites W2107694585 @default.
• W2031438670 cites W2110065044 @default.
• W2031438670 cites W2111667895 @default.
• W2031438670 cites W2116472461 @default.
• W2031438670 cites W2118708320 @default.
• W2031438670 cites W2119046587 @default.
• W2031438670 cites W2120778027 @default.
• W2031438670 cites W2122367003 @default.
• W2031438670 cites W2130147841 @default.
• W2031438670 cites W2130223580 @default.
• W2031438670 cites W2138271826 @default.
• W2031438670 cites W2146300801 @default.
• W2031438670 cites W2146809838 @default.
• W2031438670 cites W2147956522 @default.
• W2031438670 cites W2148483218 @default.
• W2031438670 cites W2148637648 @default.
• W2031438670 cites W2148993504 @default.
• W2031438670 cites W2152007541 @default.
• W2031438670 cites W2159510139 @default.
• W2031438670 cites W2161727276 @default.
• W2031438670 cites W2162948580 @default.
• W2031438670 cites W2163346654 @default.
• W2031438670 cites W2164568414 @default.
• W2031438670 cites W2166307667 @default.
• W2031438670 cites W2167276769 @default.

• next