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- W2031439791 abstract "Background Hepatitis C virus (HCV) chronically infects approximately 2% of the European population. Antiviral therapy with pegInterferon-α (PegIFN) and ribavirin (Rbv) is the standard of care, leading to HCV eradication in roughly 50% of patients. IFN-based therapy has been associated with high rates (20%) of central nervous system side effects, but only a few case reports exist on extrapyramidal side effects. Results We report a 64-year-old man developing parkinsonism during PegIFN alfa-2a and ribavirin therapy for chronic hepatitis C. No improvement was observed after treatment discontinuation. Therefore, on the basis of previous clinical and experimental reports, levodopa-benserazide treatment was started. After substantial improvement, symptoms relapsed following drug tapering. Conclusions This is the first case of parkinsonism in a Caucasian patient receiving PegIFN/Rbv therapy. The rapid and significant improvement of symptoms obtained in our patient with levodopa-benserazide, suggests that this therapy could be considered as first line symptomatic treatment." @default.
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- W2031439791 date "2008-07-01" @default.
- W2031439791 modified "2023-10-02" @default.
- W2031439791 title "Recovery after l-DOPA treatment in peginterferon and ribavirin induced parkinsonism" @default.
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- W2031439791 doi "https://doi.org/10.1016/j.ejim.2007.10.003" @default.
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