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• W2031439954 abstract "Background & AimsGlucagon-like peptide-2 (GLP-2) is an intestinal hormone that promotes growth of the gastrointestinal tract. Although insulin-like growth factor (IGF)-1 and the IGF-1 receptor (IGF-1R) are required for GLP-2–induced proliferation of crypt cells, little is known about localization of the IGF-1R which mediates the intestinotropic actions of GLP-2.MethodsWe examined intestinal growth and proliferative responses in mice with conditional deletion of IGF-1R from intestinal epithelial cells (IE-igf1rKO) after acute administration (30–90 min) of GLP-2, in response to 24-hour fasting and re-feeding (to induce GLP-2–dependent adaptation), and after chronic exposure (10 days) to GLP-2.ResultsIE-igf1rKO mice had normal small intestinal weight, morphometric parameters, proliferative indices, and distribution of differentiated epithelial cell lineages. Acute administration of GLP-2 increased nuclear translocation of β-catenin in non-Paneth crypt cells and stimulated the crypt–cell proliferative marker c-Myc in control but not IE-igf1rKO mice. Small intestinal weight, crypt depth, villus height, and crypt-cell proliferation were decreased in control and IE-igf1rKO mice after 24-hour fasting. Although re-feeding control mice restored all of these parameters, re-fed IE-igf1rKO mice had reductions in adaptive regrowth of the villi and crypt-cell proliferation. Control mice that were given chronic GLP-2 had increases in small intestinal weight, mucosal cross-sectional area, crypt depth, villus height, and crypt-cell proliferation. However, the GLP-2–induced increase in crypt-cell proliferation was not observed in IE-igf1rKO mice, and growth of the crypt–villus axis was reduced.ConclusionsThe proliferative responses of the intestinal epithelium to exogenous GLP-2 administration and conditions of GLP-2–dependent adaptive re-growth require the intestinal epithelial IGF-1R. Glucagon-like peptide-2 (GLP-2) is an intestinal hormone that promotes growth of the gastrointestinal tract. Although insulin-like growth factor (IGF)-1 and the IGF-1 receptor (IGF-1R) are required for GLP-2–induced proliferation of crypt cells, little is known about localization of the IGF-1R which mediates the intestinotropic actions of GLP-2. We examined intestinal growth and proliferative responses in mice with conditional deletion of IGF-1R from intestinal epithelial cells (IE-igf1rKO) after acute administration (30–90 min) of GLP-2, in response to 24-hour fasting and re-feeding (to induce GLP-2–dependent adaptation), and after chronic exposure (10 days) to GLP-2. IE-igf1rKO mice had normal small intestinal weight, morphometric parameters, proliferative indices, and distribution of differentiated epithelial cell lineages. Acute administration of GLP-2 increased nuclear translocation of β-catenin in non-Paneth crypt cells and stimulated the crypt–cell proliferative marker c-Myc in control but not IE-igf1rKO mice. Small intestinal weight, crypt depth, villus height, and crypt-cell proliferation were decreased in control and IE-igf1rKO mice after 24-hour fasting. Although re-feeding control mice restored all of these parameters, re-fed IE-igf1rKO mice had reductions in adaptive regrowth of the villi and crypt-cell proliferation. Control mice that were given chronic GLP-2 had increases in small intestinal weight, mucosal cross-sectional area, crypt depth, villus height, and crypt-cell proliferation. However, the GLP-2–induced increase in crypt-cell proliferation was not observed in IE-igf1rKO mice, and growth of the crypt–villus axis was reduced. The proliferative responses of the intestinal epithelium to exogenous GLP-2 administration and conditions of GLP-2–dependent adaptive re-growth require the intestinal epithelial IGF-1R." @default.
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• W2031439954 date "2011-12-01" @default.
• W2031439954 modified "2023-10-15" @default.
• W2031439954 title "Loss of Glucagon-Like Peptide-2–Induced Proliferation Following Intestinal Epithelial Insulin-Like Growth Factor-1–Receptor Deletion" @default.
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• W2031439954 doi "https://doi.org/10.1053/j.gastro.2011.09.014" @default.
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