FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031453575> ?p ?o ?g. }

• W2031453575 endingPage "439" @default.
• W2031453575 startingPage "431" @default.
• W2031453575 abstract "Convolutamydine A, an oxindole that originated from a marine bryozoan, has several biological effects. In this study, we aimed to investigate the antinociceptive effects of convolutamydine A and two new synthetic analogues. Convolutamydine A and the two analogues were given orally to assess their ability to induce antinociceptive effects. Formalin-induced licking response, acetic acid-induced contortions, and hot plate models were used to characterize the effects of convolutamydine A and its analogues. Convolutamydine A (4,6-bromo-3-(2-oxopropyl)-3-hydroxy-2-oxindole), compound 1 (3-(2-oxopropyl)-3-hydroxy-2-oxindole), and compound 2 (5-bromo-3-(2-oxopropyl)-3-hydroxy-2-oxindole) caused peripheral antinociceptive and anti-inflammatory effects in the acetic acid-induced contortions and the formalin-induced licking models. Supraspinal effects were also observed in the hot plate model and were similar to those obtained with morphine. The peripheral effects were not mediated by the cholinergic or opioid systems. The antinociceptive effects of convolutamydine A seem to be mediated by all three systems (cholinergic, opioid, and nitric oxide systems), and the mechanism of action of compounds 1 and 2 involved cholinergic and nitric oxide-mediated mechanisms. Convolutamydine A and its analogues (compounds 1 and 2) showed good antinociceptive ability after systemic administration in acute pain models. The antinociceptive action mediated by cholinergic, opioid, and nitric oxide systems could explain why convolutamydine A, compound 1, and compound 2 retained their antinociceptive effects. The doses used were similar to the doses of morphine and were much lower than that of acetylsalicylic acid, the classical analgesic and anti-inflammatory drug. In conclusion, convolutamydine A and the two analogues demonstrated antinociceptive effects comparable to morphine's effects." @default.
• W2031453575 created "2016-06-24" @default.
• W2031453575 creator A5009642349 @default.
• W2031453575 creator A5017885327 @default.
• W2031453575 creator A5042421367 @default.
• W2031453575 creator A5067786337 @default.
• W2031453575 creator A5080581796 @default.
• W2031453575 creator A5061053656 @default.
• W2031453575 date "2013-01-01" @default.
• W2031453575 modified "2023-10-14" @default.
• W2031453575 title "Convolutamydine A and synthetic analogues have antinociceptive properties in mice" @default.
• W2031453575 cites W1964738318 @default.
• W2031453575 cites W1965762284 @default.
• W2031453575 cites W1966794207 @default.
• W2031453575 cites W1969144595 @default.
• W2031453575 cites W1974356082 @default.
• W2031453575 cites W1975763112 @default.
• W2031453575 cites W1977113865 @default.
• W2031453575 cites W1978309512 @default.
• W2031453575 cites W1986115742 @default.
• W2031453575 cites W1986244573 @default.
• W2031453575 cites W1989491322 @default.
• W2031453575 cites W1990612658 @default.
• W2031453575 cites W1991409478 @default.
• W2031453575 cites W1995074964 @default.
• W2031453575 cites W2007540811 @default.
• W2031453575 cites W2008248479 @default.
• W2031453575 cites W2009345240 @default.
• W2031453575 cites W2010965582 @default.
• W2031453575 cites W2012553513 @default.
• W2031453575 cites W2017870121 @default.
• W2031453575 cites W2019881647 @default.
• W2031453575 cites W2022203178 @default.
• W2031453575 cites W2031860793 @default.
• W2031453575 cites W2035340130 @default.
• W2031453575 cites W2035598134 @default.
• W2031453575 cites W2037958223 @default.
• W2031453575 cites W2038168100 @default.
• W2031453575 cites W2042464457 @default.
• W2031453575 cites W2047799441 @default.
• W2031453575 cites W2050059016 @default.
• W2031453575 cites W2050072421 @default.
• W2031453575 cites W2051690250 @default.
• W2031453575 cites W2053050435 @default.
• W2031453575 cites W2053794393 @default.
• W2031453575 cites W2056446204 @default.
• W2031453575 cites W2057233762 @default.
• W2031453575 cites W2059944512 @default.
• W2031453575 cites W2064175661 @default.
• W2031453575 cites W2068227193 @default.
• W2031453575 cites W2068504514 @default.
• W2031453575 cites W2073541816 @default.
• W2031453575 cites W2075275942 @default.
• W2031453575 cites W2077130117 @default.
• W2031453575 cites W2081929515 @default.
• W2031453575 cites W2084131699 @default.
• W2031453575 cites W2087263689 @default.
• W2031453575 cites W2087454739 @default.
• W2031453575 cites W2090803213 @default.
• W2031453575 cites W2094815060 @default.
• W2031453575 cites W2109503514 @default.
• W2031453575 cites W2109955163 @default.
• W2031453575 cites W2128788119 @default.
• W2031453575 cites W2133538529 @default.
• W2031453575 cites W2134993428 @default.
• W2031453575 cites W2144441343 @default.
• W2031453575 cites W2145072040 @default.
• W2031453575 cites W2152763690 @default.
• W2031453575 cites W2950465214 @default.
• W2031453575 cites W2952420819 @default.
• W2031453575 doi "https://doi.org/10.1016/j.pbb.2012.09.023" @default.
• W2031453575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23046852" @default.
• W2031453575 hasPublicationYear "2013" @default.
• W2031453575 type Work @default.
• W2031453575 sameAs 2031453575 @default.
• W2031453575 citedByCount "38" @default.
• W2031453575 countsByYear W20314535752013 @default.
• W2031453575 countsByYear W20314535752014 @default.
• W2031453575 countsByYear W20314535752015 @default.
• W2031453575 countsByYear W20314535752016 @default.
• W2031453575 countsByYear W20314535752017 @default.
• W2031453575 countsByYear W20314535752018 @default.
• W2031453575 countsByYear W20314535752019 @default.
• W2031453575 countsByYear W20314535752020 @default.
• W2031453575 countsByYear W20314535752021 @default.
• W2031453575 countsByYear W20314535752022 @default.
• W2031453575 countsByYear W20314535752023 @default.
• W2031453575 crossrefType "journal-article" @default.
• W2031453575 hasAuthorship W2031453575A5009642349 @default.
• W2031453575 hasAuthorship W2031453575A5017885327 @default.
• W2031453575 hasAuthorship W2031453575A5042421367 @default.
• W2031453575 hasAuthorship W2031453575A5061053656 @default.
• W2031453575 hasAuthorship W2031453575A5067786337 @default.
• W2031453575 hasAuthorship W2031453575A5080581796 @default.
• W2031453575 hasBestOaLocation W20314535751 @default.
• W2031453575 hasConcept C126322002 @default.
• W2031453575 hasConcept C15490471 @default.
• W2031453575 hasConcept C170493617 @default.

• next