FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031455336> ?p ?o ?g. }

• W2031455336 endingPage "46" @default.
• W2031455336 startingPage "39" @default.
• W2031455336 abstract "T cells are intimately involved in the etiology and pathogenesis of human autoimmune thyroid disease. In order to further elucidate the immunologic mechanisms leading to Graves' disease (GD), we investigated the effects of human lymphocytes derived from patients with autoimmune and nonautoimmune thyroid diseases on human thyroid tissue xenotransplanted into nude mice. Eight weeks after transplantation of thyroid tissue from 26 patients with nonautoimmune thyroid disease (nontoxic nodular goiter [NTG]) into nude mice, peripheral (PBL) and intrathyroidal lymphocytes (ITL) from 14 patients with NTG and 12 patients with GD were engrafted into the animals. ITL and PBL subsets were analyzed by flow cytometer before engraftment. Two days after lymphocyte engraftment, the thyroid transplants were examined histologically (HE) as well as immunohistologically by staining with monoclonal antibodies directed against CD3 (T-cell activation and signal transduction), immunoglobulin G (IgG), HLA class II and CD31 (human endothelium). After injection of GD lymphocytes, thyroid transplants contained significantly more CD3, HLA class II, and CD4 expressing cells. Engrafted PBL and especially ITL from patients with GD specifically migrated into human thyroid transplants but not into the mouse thyroids, induced expression of class II products and led to IgG production by plasma cells. Persistence of human endothelium has been proven by positive CD31 staining. In conclusion, our data demonstrate that an organ-specific immune response is induced only by GD lymphocytes that migrate specifically into the thyroid transplants. Persistence of human endothelial cells in the transplants suggests that homing in this in vivo model reflects the situation in GD patients." @default.
• W2031455336 created "2016-06-24" @default.
• W2031455336 creator A5010984420 @default.
• W2031455336 creator A5017052355 @default.
• W2031455336 creator A5046028267 @default.
• W2031455336 creator A5082076627 @default.
• W2031455336 date "1999-01-01" @default.
• W2031455336 modified "2023-09-26" @default.
• W2031455336 title "Immunologic Effects of Human Peripheral and Intrathyroidal Lymphocytes on Xenotransplanted Human Thyroid Tissue in Athymic Nude Mice" @default.
• W2031455336 cites W1523465672 @default.
• W2031455336 cites W155421318 @default.
• W2031455336 cites W1562637495 @default.
• W2031455336 cites W1596747967 @default.
• W2031455336 cites W1967191182 @default.
• W2031455336 cites W1972729315 @default.
• W2031455336 cites W1973078931 @default.
• W2031455336 cites W1981028029 @default.
• W2031455336 cites W1982125977 @default.
• W2031455336 cites W1984692233 @default.
• W2031455336 cites W1987125351 @default.
• W2031455336 cites W1987390467 @default.
• W2031455336 cites W1991401234 @default.
• W2031455336 cites W1992758569 @default.
• W2031455336 cites W1994135361 @default.
• W2031455336 cites W2004174007 @default.
• W2031455336 cites W2014206011 @default.
• W2031455336 cites W2014617505 @default.
• W2031455336 cites W2018276288 @default.
• W2031455336 cites W2020040437 @default.
• W2031455336 cites W2021475867 @default.
• W2031455336 cites W2021847833 @default.
• W2031455336 cites W2027372806 @default.
• W2031455336 cites W2032518444 @default.
• W2031455336 cites W2034843803 @default.
• W2031455336 cites W2037971642 @default.
• W2031455336 cites W2038535438 @default.
• W2031455336 cites W2041957367 @default.
• W2031455336 cites W2041994695 @default.
• W2031455336 cites W2042626190 @default.
• W2031455336 cites W2044611871 @default.
• W2031455336 cites W2047259779 @default.
• W2031455336 cites W2048821124 @default.
• W2031455336 cites W2049754499 @default.
• W2031455336 cites W2053278781 @default.
• W2031455336 cites W2057133278 @default.
• W2031455336 cites W2058301184 @default.
• W2031455336 cites W2065001328 @default.
• W2031455336 cites W2066547218 @default.
• W2031455336 cites W2068952887 @default.
• W2031455336 cites W2073901267 @default.
• W2031455336 cites W2074903324 @default.
• W2031455336 cites W2080666305 @default.
• W2031455336 cites W2085947216 @default.
• W2031455336 cites W2088202416 @default.
• W2031455336 cites W2090353751 @default.
• W2031455336 cites W2116525621 @default.
• W2031455336 cites W2119834994 @default.
• W2031455336 cites W2154239564 @default.
• W2031455336 cites W2272516649 @default.
• W2031455336 cites W2398252620 @default.
• W2031455336 cites W2409798282 @default.
• W2031455336 cites W2417893382 @default.
• W2031455336 cites W39478977 @default.
• W2031455336 cites W72857402 @default.
• W2031455336 doi "https://doi.org/10.1089/thy.1999.9.39" @default.
• W2031455336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10037075" @default.
• W2031455336 hasPublicationYear "1999" @default.
• W2031455336 type Work @default.
• W2031455336 sameAs 2031455336 @default.
• W2031455336 citedByCount "3" @default.
• W2031455336 crossrefType "journal-article" @default.
• W2031455336 hasAuthorship W2031455336A5010984420 @default.
• W2031455336 hasAuthorship W2031455336A5017052355 @default.
• W2031455336 hasAuthorship W2031455336A5046028267 @default.
• W2031455336 hasAuthorship W2031455336A5082076627 @default.
• W2031455336 hasConcept C114684123 @default.
• W2031455336 hasConcept C126322002 @default.
• W2031455336 hasConcept C142724271 @default.
• W2031455336 hasConcept C167672396 @default.
• W2031455336 hasConcept C203014093 @default.
• W2031455336 hasConcept C204232928 @default.
• W2031455336 hasConcept C2778939058 @default.
• W2031455336 hasConcept C2911091166 @default.
• W2031455336 hasConcept C526584372 @default.
• W2031455336 hasConcept C71924100 @default.
• W2031455336 hasConcept C8891405 @default.
• W2031455336 hasConceptScore W2031455336C114684123 @default.
• W2031455336 hasConceptScore W2031455336C126322002 @default.
• W2031455336 hasConceptScore W2031455336C142724271 @default.
• W2031455336 hasConceptScore W2031455336C167672396 @default.
• W2031455336 hasConceptScore W2031455336C203014093 @default.
• W2031455336 hasConceptScore W2031455336C204232928 @default.
• W2031455336 hasConceptScore W2031455336C2778939058 @default.
• W2031455336 hasConceptScore W2031455336C2911091166 @default.
• W2031455336 hasConceptScore W2031455336C526584372 @default.
• W2031455336 hasConceptScore W2031455336C71924100 @default.
• W2031455336 hasConceptScore W2031455336C8891405 @default.
• W2031455336 hasIssue "1" @default.

• next