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- W2031456080 abstract "Cytomegalovirus (CMV) infection and delayed immune reconstitution remains a serious obstacle for successful partially matched-related donor transplantation (PMRD). We evaluated 42 patients for the development of CMV-specific CD8+ T lymphocytes (CTL(CMV) ) following granulocyte colony-stimulating factor-primed peripheral blood (PB) and bone marrow (BM) with anti-thymocyte globulin (ATG)-based PMRD. PMRD recipients achieved a high frequency, proliferation capacity, and interferon-γ response of CTL(CMV) at 1 year post transplantation. CTL(CMV) with the central memory CD45RO+CD62L+ cell phenotype expanded in PB and BM-resident CTL(CMV) displayed distinct phenotypes when CMV was reactivated. Although the incidence of CMV reactivation was high in PMRD patients (87.67%), only 11.90% of them developed CMV disease. In conclusion, after PMRD using mixed grafts with ATG-based conditioning, immune recovery to CMV seems to be early and fast, thereby reducing the incidence of CMV disease." @default.
- W2031456080 created "2016-06-24" @default.
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- W2031456080 date "2012-02-29" @default.
- W2031456080 modified "2023-10-15" @default.
- W2031456080 title "Immune reconstitution to cytomegalovirus following partially matched-related donor transplantation: impact ofin vivoT-cell depletion and granulocyte colony-stimulating factor-primed peripheral blood/bone marrow mixed grafts" @default.
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- W2031456080 doi "https://doi.org/10.1111/j.1399-3062.2012.00722.x" @default.
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