FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031477909> ?p ?o ?g. }

• W2031477909 endingPage "1026" @default.
• W2031477909 startingPage "1009" @default.
• W2031477909 abstract "Surface coating is the simplest surface modification. However, bioactive molecules can not spread well on the commonly used polylactone-type skeletons; thus, the surface coatings of biomolecules are typically unstable due to the weak interaction between the polymer and the bioactive molecules. In this study, a special type of poly(lactide-co-glycolide) (PLGA)-based scaffold with a loosened skeleton was fabricated by phase separation, which allowed gelatin molecules to more readily diffuse throughout the structure. In this application, gelatin modified both the internal substrate and external surface. After cross-linking with glutaraldehyde, the surface layer gelatin was tightly bound to the diffused gelatin, thereby preventing the surface layer gelatin coating from falling off within 14 days. After gelatin modification, PLGA scaffold demonstrated enhanced hydrophilicity and improved mechanical properties (i.e., increased compression strength and elastic modulus) in dry and wet states. Furthermore, a sustained release profile of recombinant human bone morphogenetic protein-2 (rhBMP-2) was achieved in the coated scaffold. The coated scaffold also supported the in vitro attachment, proliferation, and osteogenesis of rabbit bone mesenchymal stem cells (BMSCs), indicating the bioactivity of rhBMP-2. These results collectively demonstrate that the cross-linked-gelatin-coated porous PLGA scaffold incorporating bioactive molecules is a promising candidate for bone tissue regeneration." @default.
• W2031477909 created "2016-06-24" @default.
• W2031477909 creator A5010491128 @default.
• W2031477909 creator A5011786598 @default.
• W2031477909 creator A5018892762 @default.
• W2031477909 creator A5045930233 @default.
• W2031477909 creator A5049631568 @default.
• W2031477909 creator A5058280163 @default.
• W2031477909 creator A5090323662 @default.
• W2031477909 date "2015-03-10" @default.
• W2031477909 modified "2023-10-16" @default.
• W2031477909 title "Gelatin Tight-Coated Poly(lactide-co-glycolide) Scaffold Incorporating rhBMP-2 for Bone Tissue Engineering" @default.
• W2031477909 cites W1576712420 @default.
• W2031477909 cites W1578670556 @default.
• W2031477909 cites W1964723003 @default.
• W2031477909 cites W1966982456 @default.
• W2031477909 cites W1968822620 @default.
• W2031477909 cites W1980784760 @default.
• W2031477909 cites W1991018493 @default.
• W2031477909 cites W1994620171 @default.
• W2031477909 cites W1997297316 @default.
• W2031477909 cites W1997549639 @default.
• W2031477909 cites W2001528926 @default.
• W2031477909 cites W2005662457 @default.
• W2031477909 cites W2007793290 @default.
• W2031477909 cites W2011602893 @default.
• W2031477909 cites W2018176060 @default.
• W2031477909 cites W2035605658 @default.
• W2031477909 cites W2043174216 @default.
• W2031477909 cites W2056382542 @default.
• W2031477909 cites W2060181588 @default.
• W2031477909 cites W2061435194 @default.
• W2031477909 cites W2061452682 @default.
• W2031477909 cites W2063142742 @default.
• W2031477909 cites W2071625448 @default.
• W2031477909 cites W2072905377 @default.
• W2031477909 cites W2077557889 @default.
• W2031477909 cites W2079387025 @default.
• W2031477909 cites W2079405834 @default.
• W2031477909 cites W2081731500 @default.
• W2031477909 cites W2085760392 @default.
• W2031477909 cites W2087230484 @default.
• W2031477909 cites W2088322279 @default.
• W2031477909 cites W2110132731 @default.
• W2031477909 cites W2139033684 @default.
• W2031477909 cites W2145215476 @default.
• W2031477909 cites W2170969206 @default.
• W2031477909 cites W2185894794 @default.
• W2031477909 cites W2328153000 @default.
• W2031477909 doi "https://doi.org/10.3390/ma8031009" @default.
• W2031477909 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5455445" @default.
• W2031477909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787985" @default.
• W2031477909 hasPublicationYear "2015" @default.
• W2031477909 type Work @default.
• W2031477909 sameAs 2031477909 @default.
• W2031477909 citedByCount "29" @default.
• W2031477909 countsByYear W20314779092015 @default.
• W2031477909 countsByYear W20314779092016 @default.
• W2031477909 countsByYear W20314779092017 @default.
• W2031477909 countsByYear W20314779092018 @default.
• W2031477909 countsByYear W20314779092019 @default.
• W2031477909 countsByYear W20314779092020 @default.
• W2031477909 countsByYear W20314779092021 @default.
• W2031477909 countsByYear W20314779092022 @default.
• W2031477909 crossrefType "journal-article" @default.
• W2031477909 hasAuthorship W2031477909A5010491128 @default.
• W2031477909 hasAuthorship W2031477909A5011786598 @default.
• W2031477909 hasAuthorship W2031477909A5018892762 @default.
• W2031477909 hasAuthorship W2031477909A5045930233 @default.
• W2031477909 hasAuthorship W2031477909A5049631568 @default.
• W2031477909 hasAuthorship W2031477909A5058280163 @default.
• W2031477909 hasAuthorship W2031477909A5090323662 @default.
• W2031477909 hasBestOaLocation W20314779091 @default.
• W2031477909 hasConcept C115537861 @default.
• W2031477909 hasConcept C127413603 @default.
• W2031477909 hasConcept C136229726 @default.
• W2031477909 hasConcept C155672457 @default.
• W2031477909 hasConcept C159985019 @default.
• W2031477909 hasConcept C171250308 @default.
• W2031477909 hasConcept C178790620 @default.
• W2031477909 hasConcept C185592680 @default.
• W2031477909 hasConcept C192562407 @default.
• W2031477909 hasConcept C2777529624 @default.
• W2031477909 hasConcept C2778606738 @default.
• W2031477909 hasConcept C2778823387 @default.
• W2031477909 hasConcept C2780165375 @default.
• W2031477909 hasConcept C2781448156 @default.
• W2031477909 hasConcept C42360764 @default.
• W2031477909 hasConcept C49892992 @default.
• W2031477909 hasConcept C71924100 @default.
• W2031477909 hasConcept C89429830 @default.
• W2031477909 hasConceptScore W2031477909C115537861 @default.
• W2031477909 hasConceptScore W2031477909C127413603 @default.
• W2031477909 hasConceptScore W2031477909C136229726 @default.
• W2031477909 hasConceptScore W2031477909C155672457 @default.
• W2031477909 hasConceptScore W2031477909C159985019 @default.
• W2031477909 hasConceptScore W2031477909C171250308 @default.
• W2031477909 hasConceptScore W2031477909C178790620 @default.

• next