Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031481833> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2031481833 endingPage "107006" @default.
- W2031481833 startingPage "107006" @default.
- W2031481833 abstract "Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cells and subsequent loss of visual function. Early detection of glaucoma is critical for the prevention of permanent structural damage and irreversible vision loss. Raman spectroscopy is a technique that provides rapid biochemical characterization of tissues in a nondestructive and noninvasive fashion. In this study, we explored the potential of using Raman spectroscopy for detection of glaucomatous changes in vitro. Raman spectroscopic imaging was conducted on retinal tissues of dogs with hereditary glaucoma and healthy control dogs. The Raman spectra were subjected to multivariate discriminant analysis with a support vector machine algorithm, and a classification model was developed to differentiate disease tissues versus healthy tissues. Spectroscopic analysis of 105 retinal ganglion cells (RGCs) from glaucomatous dogs and 267 RGCs from healthy dogs revealed spectroscopic markers that differentiated glaucomatous specimens from healthy controls. Furthermore, the multivariate discriminant model differentiated healthy samples and glaucomatous samples with good accuracy [healthy 89.5% and glaucomatous 97.6% for the same breed (Basset Hounds); and healthy 85.0% and glaucomatous 85.5% for different breeds (Beagles versus Basset Hounds)]. Raman spectroscopic screening can be used for in vitro detection of glaucomatous changes in retinal tissue with a high specificity." @default.
- W2031481833 created "2016-06-24" @default.
- W2031481833 creator A5002534875 @default.
- W2031481833 creator A5004480369 @default.
- W2031481833 creator A5005323368 @default.
- W2031481833 creator A5015195367 @default.
- W2031481833 creator A5031706478 @default.
- W2031481833 creator A5085783862 @default.
- W2031481833 creator A5090299026 @default.
- W2031481833 date "2011-01-01" @default.
- W2031481833 modified "2023-09-27" @default.
- W2031481833 title "Exploring Raman spectroscopy for the evaluation of glaucomatous retinal changes" @default.
- W2031481833 cites W1963492300 @default.
- W2031481833 cites W1964881544 @default.
- W2031481833 cites W1967139820 @default.
- W2031481833 cites W1973266138 @default.
- W2031481833 cites W1974976299 @default.
- W2031481833 cites W1984401984 @default.
- W2031481833 cites W2012389637 @default.
- W2031481833 cites W2028245598 @default.
- W2031481833 cites W2033704410 @default.
- W2031481833 cites W2038350972 @default.
- W2031481833 cites W2058918203 @default.
- W2031481833 cites W2062123859 @default.
- W2031481833 cites W2063291201 @default.
- W2031481833 cites W2085107102 @default.
- W2031481833 cites W2090674515 @default.
- W2031481833 cites W2097358067 @default.
- W2031481833 cites W2101533555 @default.
- W2031481833 cites W2116033780 @default.
- W2031481833 cites W2127673401 @default.
- W2031481833 cites W2139695214 @default.
- W2031481833 cites W2144517997 @default.
- W2031481833 cites W2158761853 @default.
- W2031481833 cites W2160564267 @default.
- W2031481833 cites W2160797083 @default.
- W2031481833 cites W2303501228 @default.
- W2031481833 cites W4245839829 @default.
- W2031481833 doi "https://doi.org/10.1117/1.3642010" @default.
- W2031481833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22029368" @default.
- W2031481833 hasPublicationYear "2011" @default.
- W2031481833 type Work @default.
- W2031481833 sameAs 2031481833 @default.
- W2031481833 citedByCount "9" @default.
- W2031481833 countsByYear W20314818332013 @default.
- W2031481833 countsByYear W20314818332018 @default.
- W2031481833 countsByYear W20314818332019 @default.
- W2031481833 countsByYear W20314818332020 @default.
- W2031481833 countsByYear W20314818332023 @default.
- W2031481833 crossrefType "journal-article" @default.
- W2031481833 hasAuthorship W2031481833A5002534875 @default.
- W2031481833 hasAuthorship W2031481833A5004480369 @default.
- W2031481833 hasAuthorship W2031481833A5005323368 @default.
- W2031481833 hasAuthorship W2031481833A5015195367 @default.
- W2031481833 hasAuthorship W2031481833A5031706478 @default.
- W2031481833 hasAuthorship W2031481833A5085783862 @default.
- W2031481833 hasAuthorship W2031481833A5090299026 @default.
- W2031481833 hasBestOaLocation W20314818331 @default.
- W2031481833 hasConcept C118487528 @default.
- W2031481833 hasConcept C120665830 @default.
- W2031481833 hasConcept C121332964 @default.
- W2031481833 hasConcept C142724271 @default.
- W2031481833 hasConcept C2778527774 @default.
- W2031481833 hasConcept C2780827179 @default.
- W2031481833 hasConcept C40003534 @default.
- W2031481833 hasConcept C71924100 @default.
- W2031481833 hasConceptScore W2031481833C118487528 @default.
- W2031481833 hasConceptScore W2031481833C120665830 @default.
- W2031481833 hasConceptScore W2031481833C121332964 @default.
- W2031481833 hasConceptScore W2031481833C142724271 @default.
- W2031481833 hasConceptScore W2031481833C2778527774 @default.
- W2031481833 hasConceptScore W2031481833C2780827179 @default.
- W2031481833 hasConceptScore W2031481833C40003534 @default.
- W2031481833 hasConceptScore W2031481833C71924100 @default.
- W2031481833 hasIssue "10" @default.
- W2031481833 hasLocation W20314818331 @default.
- W2031481833 hasLocation W20314818332 @default.
- W2031481833 hasLocation W20314818333 @default.
- W2031481833 hasOpenAccess W2031481833 @default.
- W2031481833 hasPrimaryLocation W20314818331 @default.
- W2031481833 hasRelatedWork W1602916030 @default.
- W2031481833 hasRelatedWork W1894388108 @default.
- W2031481833 hasRelatedWork W2466551580 @default.
- W2031481833 hasRelatedWork W2743388083 @default.
- W2031481833 hasRelatedWork W2747239022 @default.
- W2031481833 hasRelatedWork W2964242007 @default.
- W2031481833 hasRelatedWork W3030884666 @default.
- W2031481833 hasRelatedWork W3031683060 @default.
- W2031481833 hasRelatedWork W596059659 @default.
- W2031481833 hasRelatedWork W938964708 @default.
- W2031481833 hasVolume "16" @default.
- W2031481833 isParatext "false" @default.
- W2031481833 isRetracted "false" @default.
- W2031481833 magId "2031481833" @default.
- W2031481833 workType "article" @default.