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- W2031497406 abstract "The microtubule (MT) cytoskeleton of a mature axon is maintained in a stabilized steady state, yet after axonal injury it can be transformed into a dynamic structure capable of supporting axon regrowth. Using Caenorhabditis elegans mechanosensory axons and in vivo imaging, we find that, in mature axons, the growth of MTs is restricted in the steady state by the depolymerizing kinesin-13 family member KLP-7. After axon injury, we observe a two-phase process of MT growth upregulation. First, the number of growing MTs increases at the injury site, concomitant with local downregulation of KLP-7. A second phase of persistent MT growth requires the cytosolic carboxypeptidase CCPP-6, which promotes Δ2 modification of α-tubulin. Both phases of MT growth are coordinated by the DLK-1 MAP kinase cascade. Our results define how the stable MT cytoskeleton of a mature neuron is converted into the dynamically growing MT cytoskeleton of a regrowing axon." @default.
- W2031497406 created "2016-06-24" @default.
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- W2031497406 date "2012-10-01" @default.
- W2031497406 modified "2023-10-14" @default.
- W2031497406 title "Kinesin-13 and Tubulin Posttranslational Modifications Regulate Microtubule Growth in Axon Regeneration" @default.
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- W2031497406 cites W1876616931 @default.
- W2031497406 cites W1893566722 @default.
- W2031497406 cites W1965404941 @default.
- W2031497406 cites W1966089167 @default.
- W2031497406 cites W1968195620 @default.
- W2031497406 cites W1970315917 @default.
- W2031497406 cites W1973756588 @default.
- W2031497406 cites W1974151854 @default.
- W2031497406 cites W1974403366 @default.
- W2031497406 cites W1985709969 @default.
- W2031497406 cites W1987014667 @default.
- W2031497406 cites W1989901971 @default.
- W2031497406 cites W1993366467 @default.
- W2031497406 cites W1995078336 @default.
- W2031497406 cites W1999168255 @default.
- W2031497406 cites W2003653198 @default.
- W2031497406 cites W2004285818 @default.
- W2031497406 cites W2006227936 @default.
- W2031497406 cites W2013500926 @default.
- W2031497406 cites W2017688356 @default.
- W2031497406 cites W2019496513 @default.
- W2031497406 cites W2023248091 @default.
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- W2031497406 cites W2037066635 @default.
- W2031497406 cites W2046089519 @default.
- W2031497406 cites W2047946886 @default.
- W2031497406 cites W2050084837 @default.
- W2031497406 cites W2051440844 @default.
- W2031497406 cites W2052935966 @default.
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- W2031497406 doi "https://doi.org/10.1016/j.devcel.2012.08.010" @default.
- W2031497406 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3477258" @default.
- W2031497406 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23000142" @default.
- W2031497406 hasPublicationYear "2012" @default.
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