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• W2031499121 abstract "<h3>Background</h3> Although deep hypothermic circulatory arrest has been extensively used in neonates for aortic arch surgery, the brain and other organs might be adversely affected by prolonged ischemia and deep hypothermia. <h3>Methods</h3> Between December 1997 and January 2005, 70 consecutive neonates underwent Norwood stage I procedure for hypoplastic left heart syndrome (group A, n=30), or aortic arch repair for interruption or coarctation with arch hypoplasia (group B, n=40), with antegrade selective cerebral perfusion (ASCP). Mean weights were 3.0 ± 0.2 kg and 2.8 ± 0.07 kg, and mean ages were 10 ± 3.5 days and 14 ± 10.6 days in groups A and B, respectively. Only 2 patients were older than 30 days. Core body temperature was lowered to 25°C, and mean pump flow during ASCP was initiated at 10 to 20 mL/(kg · min) and adjusted to guarantee a radial/temporal artery pressure of 30 to 40 mm Hg and venous oxygen saturation of more than 70%. Hematocrit was maintained at 30%. <h3>Results</h3> Early mortality was 17% (group A, 23%; group B, 12.5%; <i>p</i> = 0.19). Six late deaths occurred (3 in each group), and at 36 months, Kaplan-Meier overall survival was 64% ± 9.2% in group A and 85% ± 5.7% in group B. One patient had postoperative seizures. Age, weight, sex, prematurity, group A, and ASCP duration did not influence early mortality. <h3>Conclusions</h3> Antegrade selective cerebral perfusion is a safe and effective procedure and might improve outcome of neonatal aortic arch surgery, minimizing neurologic impact without the need for deep hypothermia." @default.
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• W2031499121 date "2006-12-01" @default.
• W2031499121 modified "2023-10-16" @default.
• W2031499121 title "Moderately Hypothermic Cardiopulmonary Bypass and Low-Flow Antegrade Selective Cerebral Perfusion for Neonatal Aortic Arch Surgery" @default.
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• W2031499121 doi "https://doi.org/10.1016/j.athoracsur.2006.06.042" @default.
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