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- W2031500914 abstract "Following single viruses on their journey through a host cell provides valuable insights that help to understand the infection process. Fluorescent labeling techniques together with high-resolution microscopic imaging allows tracking of single viruses on living cells with high temporal and spatial accuracy. Influenza A viruses were fluorescently labeled without interfering with their biological activity. Single-virus trajectories were recorded on the surface and inside living cells of different permissive cell lines. By using conventional computational methods we extracted the position of viruses within each image frame. In addition, we have applied a recently developed mathematical tool to further analyze a special type of recurrent trajectory obtained at the surface of living cells. using this approach we can identify and characterize microdomains on the cell surface. We show that the viruses are surprisingly mobile and display a variety of different types of movement, which depend on the studied cell line. The cell surface was characterized by scanning electron microscopy (SEM) and revealed a unique topography that also strongly depends on the cell type and the cells growth state. By comparing trajectories obtained from two permissive cell lines we were able to correlate the distinctive behavior of single viruses with the cell surface ultrastructure. We used cells that are infected to a different degree and combine this with virus uptake and intracellular fusion kinetics. This allows us to draw a comprehensive picture of the first steps of virus infection. Further we can draw conclusions about the infectivity and could explain why some cells are permissive while others are not." @default.
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- W2031500914 date "2013-01-01" @default.
- W2031500914 modified "2023-09-30" @default.
- W2031500914 title "Single Influenza Virus Tracking Reveals Cell Specific Modes of Movement - a Key to Understand Cellular Tropism" @default.
- W2031500914 doi "https://doi.org/10.1016/j.bpj.2012.11.2315" @default.
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