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• W2031505315 abstract "The abilitity to culture immature forms (schistosomules) and to maintain adult worms of Schistosoma mansoni has made possible a study in vitro of immunological phenomena in human and experimental schistosomiasis. The existence of a lethal factor leading to cytolysis of the schistosomules within a period of 4 days has been demonstrated in the serum of 74 per cent of patients with S. mansoni schistosomiasis. A significant relationship was found between the presence of the lethal factor and the hepatosplenic form of the disease. This lethal factor was also present in the rabbit and in the rat infected with S. mansoni cercariae and ultrastructural studies have revealed lesions in the surface of the schistosomules. The absence of lethal activity in sera from infections with S. haematobium appears to indicate a certain specificity of the action of the antibody. Moreover, this lethal factor seems of the stage specific, the same sera being without effect on adult schistosomes. Hyperimmunization of rabbits with soluble extracts of S. mansoni adults stimulated the formation of antibodies inactive on schistosomules but cytotoxic for adult schistosomes grown in vitro. The activity which was in the IgG fraction, depended on labile factors in fresh serum. This antibody is not directed against surface antigens. Ultrastructural studies of adult worms show that lesions do not affect the surface of the worm. These experiments seem to indicate that schistosomules are sensitive to antibodies produced in natural or experimental infection. While the adult worms are sensitive to the antibodies induced by immunization with extracts of adult worms, they are not affected by antibodies from natural or experimental infections. Though it does not appear that lethal antibody can be related to immunity, it may have some significance in immunopathology of schistosomiasis in man. The production of a cytotoxic antibody to adult schistosomes may represent a different approach of in vitro studies of the effects of antibodies on schistosomes." @default.
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• W2031505315 date "1974-12-01" @default.
• W2031505315 modified "2023-10-16" @default.
• W2031505315 title "Etude in vitro des phenomenes immunologiques dans la schistosomiase humaine et experimentale—I. Etude comparative in vitro de l'activite lethale d'immunserums sur les formes immatures et sur les adultes de Schistosoma mansoni" @default.
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• W2031505315 doi "https://doi.org/10.1016/0020-7519(74)90026-5" @default.
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