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- W2031508422 abstract "Summary The influence of the I region of the major histocompatibility complex (MHC) on T–dependent immune responses against a purified schistosome antigen (9B antigen) was investigated. H–2 congenic mice expressing both I–A and I–E antigens (I–E+) showed a higher in–vitro proliferation to 9B antigen as compared to the recombinant strains expressing only I–A (I–E–). These two strains of mice differed both qualitatively and quantitatively in the humoral responses elicited by the purified antigen. Furthermore, in–vivo protection experiments showed that mice which do not express I–E molecules can be partially protected against the disease by prior immunization with the 9B antigen in contrast to their I–E expressing counterparts. The possible role of the I–E molecule in the immune responses elicited during Schistosoma mansoni infection is discussed." @default.
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- W2031508422 date "1989-11-01" @default.
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- W2031508422 title "Genetic control of immune response to a purified Schistosoma mansoni antigen. I. Effect of MHC class II antigens on the cellular, humoral and protective responses" @default.
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- W2031508422 doi "https://doi.org/10.1111/j.1365-3024.1989.tb00928.x" @default.
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