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• W2031508765 abstract "The activity of polymeric DNA polymerase isolated from the cytoplasm of baby hamster kidney cells is sensitive to inhibition by heparin, whereas that of nuclear DNA polymerase is resistant. Under conditions of partial inhibition, heparin brings about a change in both the Km and V values and a twofold decrease in the ability to utilize DNA templates. Heparin effectively blocks DNA synthesis irrespective of the time of addition or conditions of preincubation with the reaction components. Upon interaction with heparin, polymeric DNA polymerase undergoes dissociation accompanied by the formation of a new species of active enzyme sedimenting at 5.3S which is partially resistant to inhibition by excess heparin. High ionic strength (0.45 m) dissociates the polymeric enzyme into active dimers and monomers irrespective of the presence of heparin. The differential susceptibility of polymeric DNA polymerase into monomeric enzyme, which resembles nuclear DNA polymerase, probably reflects a conformational change during dissociation." @default.
• W2031508765 created "2016-06-24" @default.
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• W2031508765 date "1974-10-01" @default.
• W2031508765 modified "2023-09-23" @default.
• W2031508765 title "Inhibition and dissociation of mammalian polymeric DNA polymerase by heparin" @default.
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• W2031508765 doi "https://doi.org/10.1016/0003-9861(74)90050-2" @default.
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