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• W2031508853 abstract "The recruitment of cohesins to pericentric chromatin in some organisms appears to require heterochromatin associated with repetitive DNA. However, neocentromeres and budding yeast centromeres lack flanking repetitive DNA, indicating that cohesin recruitment occurs through an alternative pathway. Here, we demonstrate that all budding yeast chromosomes assemble cohesin domains that extend over 20-50 kb of unique pericentric sequences flanking the conserved 120-bp centromeric DNA. The assembly of these cohesin domains requires the presence of a functional kinetochore in every cell cycle. A similar enhancement of cohesin binding was also observed in regions flanking an ectopic centromere. At both endogenous and ectopic locations, the centromeric enhancer amplified the inherent levels of cohesin binding that are unique to each region. Thus, kinetochores are enhancers of cohesin association that act over tens of kilobases to assemble pericentric cohesin domains. These domains are larger than the pericentric regions stretched by microtubule attachments, and thus are likely to counter microtubule-dependent forces. Kinetochores mediate two essential segregation functions: chromosome movement through microtubule attachment and biorientation of sister chromatids through the recruitment of high levels of cohesin to pericentric regions. We suggest that the coordination of chromosome movement and biorientation makes the kinetochore an autonomous segregation unit." @default.
• W2031508853 created "2016-06-24" @default.
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• W2031508853 date "2004-07-27" @default.
• W2031508853 modified "2023-10-04" @default.
• W2031508853 title "The Kinetochore Is an Enhancer of Pericentric Cohesin Binding" @default.
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• W2031508853 doi "https://doi.org/10.1371/journal.pbio.0020260" @default.
• W2031508853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/490027" @default.
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• W2031508853 hasPublicationYear "2004" @default.
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