FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031511436> ?p ?o ?g. }

• W2031511436 endingPage "479" @default.
• W2031511436 startingPage "469" @default.
• W2031511436 abstract "<i>Background:</i> Hypoxia causes heterogeneous contractile responses in resistance and conduit pulmonary as well as systemic (mesenteric) artery smooth muscle cells (RPASMCs, CPASMCs and MASMCs), but the underlying mechanisms are largely unknown. In this study, we aimed to investigate whether the gene expression and functional activity of ryanodine receptors (RyRs) would be different in these 3 cell types. <i>Methods:</i> RyR mRNA expression, Ca²⁺ sparks and [Ca²⁺]_i were measured by real-time quantitative RT-PCR, laser scanning confocal microscopy and wide-field fluorescence microscopy, respectively. <i>Results:</i> All 3 RyR subtype (RyR1, RyR2 and RyR3) mRNAs are expressed in RPASMCs, CPASMCs and MASMCs, but their expression levels are different. Spontaneous Ca²⁺ sparks (functional events of RyRs) show distinct frequency, amplitude, duration, size and kinetics in these 3 cell types. Similarly, activation of RyRs by caffeine, 4-chloro-m-cresol or high K⁺ induces differential Ca²⁺ release. Moreover, hypoxia-induced increase in [Ca²⁺]_i is largest in MASMCs relative to CPSAMCs and smallest in RPASMCs. <i>Conclusion:</i> This study provides comprehensive evidence that RyRs are heterogeneous in gene expression and functional activity in RPASMCs, CPASMCs and MASMCs, which may contribute to the diversity of excitation-contraction coupling and hypoxic Ca²⁺ responses in different vascular smooth muscle cells." @default.
• W2031511436 created "2016-06-24" @default.
• W2031511436 creator A5013260624 @default.
• W2031511436 creator A5042847462 @default.
• W2031511436 creator A5050924752 @default.
• W2031511436 creator A5060177975 @default.
• W2031511436 creator A5068884694 @default.
• W2031511436 creator A5080373597 @default.
• W2031511436 date "2008-01-01" @default.
• W2031511436 modified "2023-10-15" @default.
• W2031511436 title "Heterogeneous Gene Expression and Functional Activity of Ryanodine Receptors in Resistance and Conduit Pulmonary as well as Mesenteric Artery Smooth Muscle Cells" @default.
• W2031511436 cites W145922606 @default.
• W2031511436 cites W1518598287 @default.
• W2031511436 cites W1526317775 @default.
• W2031511436 cites W1547730299 @default.
• W2031511436 cites W1589364751 @default.
• W2031511436 cites W1965345723 @default.
• W2031511436 cites W1965821763 @default.
• W2031511436 cites W1970947259 @default.
• W2031511436 cites W1973987812 @default.
• W2031511436 cites W1976151623 @default.
• W2031511436 cites W1977880193 @default.
• W2031511436 cites W1983103788 @default.
• W2031511436 cites W1986117743 @default.
• W2031511436 cites W2000551229 @default.
• W2031511436 cites W2008446620 @default.
• W2031511436 cites W2010482318 @default.
• W2031511436 cites W2010766452 @default.
• W2031511436 cites W2018507573 @default.
• W2031511436 cites W2019345683 @default.
• W2031511436 cites W2025973200 @default.
• W2031511436 cites W2052800132 @default.
• W2031511436 cites W2054225000 @default.
• W2031511436 cites W2059794282 @default.
• W2031511436 cites W2064686740 @default.
• W2031511436 cites W2066155831 @default.
• W2031511436 cites W2066537890 @default.
• W2031511436 cites W2091148180 @default.
• W2031511436 cites W2092955743 @default.
• W2031511436 cites W2092974828 @default.
• W2031511436 cites W2097414193 @default.
• W2031511436 cites W2101279699 @default.
• W2031511436 cites W2103857474 @default.
• W2031511436 cites W2114467087 @default.
• W2031511436 cites W2115688988 @default.
• W2031511436 cites W2117088919 @default.
• W2031511436 cites W2118347657 @default.
• W2031511436 cites W2124658641 @default.
• W2031511436 cites W2137283585 @default.
• W2031511436 cites W2143148805 @default.
• W2031511436 cites W2143707797 @default.
• W2031511436 cites W2146572449 @default.
• W2031511436 cites W2155161515 @default.
• W2031511436 cites W2162236977 @default.
• W2031511436 cites W2171338963 @default.
• W2031511436 cites W2171479745 @default.
• W2031511436 cites W2181344473 @default.
• W2031511436 cites W2182479674 @default.
• W2031511436 cites W2184358523 @default.
• W2031511436 cites W2266546728 @default.
• W2031511436 cites W2311570504 @default.
• W2031511436 cites W2339884335 @default.
• W2031511436 cites W2399426549 @default.
• W2031511436 cites W2402555409 @default.
• W2031511436 cites W2408804735 @default.
• W2031511436 cites W79846111 @default.
• W2031511436 doi "https://doi.org/10.1159/000127438" @default.
• W2031511436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574544" @default.
• W2031511436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18434746" @default.
• W2031511436 hasPublicationYear "2008" @default.
• W2031511436 type Work @default.
• W2031511436 sameAs 2031511436 @default.
• W2031511436 citedByCount "36" @default.
• W2031511436 countsByYear W20315114362012 @default.
• W2031511436 countsByYear W20315114362013 @default.
• W2031511436 countsByYear W20315114362014 @default.
• W2031511436 countsByYear W20315114362015 @default.
• W2031511436 countsByYear W20315114362016 @default.
• W2031511436 countsByYear W20315114362017 @default.
• W2031511436 countsByYear W20315114362018 @default.
• W2031511436 countsByYear W20315114362020 @default.
• W2031511436 countsByYear W20315114362021 @default.
• W2031511436 countsByYear W20315114362022 @default.
• W2031511436 crossrefType "journal-article" @default.
• W2031511436 hasAuthorship W2031511436A5013260624 @default.
• W2031511436 hasAuthorship W2031511436A5042847462 @default.
• W2031511436 hasAuthorship W2031511436A5050924752 @default.
• W2031511436 hasAuthorship W2031511436A5060177975 @default.
• W2031511436 hasAuthorship W2031511436A5068884694 @default.
• W2031511436 hasAuthorship W2031511436A5080373597 @default.
• W2031511436 hasBestOaLocation W20315114361 @default.
• W2031511436 hasConcept C104317684 @default.
• W2031511436 hasConcept C113217602 @default.
• W2031511436 hasConcept C126322002 @default.
• W2031511436 hasConcept C134018914 @default.
• W2031511436 hasConcept C150194340 @default.
• W2031511436 hasConcept C170493617 @default.
• W2031511436 hasConcept C185592680 @default.

• next