FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2031511904> ?p ?o ?g. }

• W2031511904 endingPage "643" @default.
• W2031511904 startingPage "631" @default.
• W2031511904 abstract "To investigate the pharmacokinetic interactions, safety, and tolerability of the combination of olmesartan medoxomil with glibenclamide.In an open, three-way crossover, phase I trial, 18 healthy adults entered three randomly ordered, seven-day treatment periods. The three treatments comprised once daily administration of (1) olmesartan 20 mg, (2) olmesartan 20 mg plus glibenclamide 3.5 mg, or (3) glibenclamide 3.5 mg.The combination of olmesartan with glibenclamide did not influence the bioequivalence of the area under the plasma-concentration time curve at steady state during one dosing interval 0 to tau = 24 hours (AUCss,tau) or the maximum steady-state concentration (Css,max) of both substances. Mean AUCss,tau values for olmesartan were 2594.8 ng h/ml for olmesartan alone and 2443.7 ng h/ml in combination with glibenclamide; the corresponding Css,max values were 479.3 ng/ml and 462.7 ng/ml, respectively. For glibenclamide, the mean AUCss,tau values were 525.7 ng x h/ml for monotherapy and 518.7 ng x h/ml for its combination with olmesartan. The median time to reach Css,max (tmax) for glibenclamide was shifted from 2.0 h to 1.0 h when combined with olmesartan, whereas the median tmax values for olmesartan remained unchanged at 1.5 h. During combined treatment with olmesartan plus glibenclamide, no adverse event occurred, and the medications were well tolerated.With the exception of a slight shift of tmax values for glibenclamide, the concomitant administration of olmesartan medoxomil with glibenclamide had no significant effects on the steady-state pharmacokinetics of either agent. This provides the pharmacokinetic rationale for clinical studies to test the combination therapy of patients with hypertension and type-2 diabetes mellitus with both compounds." @default.
• W2031511904 created "2016-06-24" @default.
• W2031511904 creator A5036062983 @default.
• W2031511904 creator A5070948074 @default.
• W2031511904 creator A5091895035 @default.
• W2031511904 date "2006-01-01" @default.
• W2031511904 modified "2023-10-18" @default.
• W2031511904 title "Pharmacokinetics and Safety of Olmesartan Medoxomil in Combination with Glibenclamide in Healthy Volunteers" @default.
• W2031511904 cites W1966000112 @default.
• W2031511904 cites W1968418627 @default.
• W2031511904 cites W1996425623 @default.
• W2031511904 cites W2000845410 @default.
• W2031511904 cites W2002779112 @default.
• W2031511904 cites W2009179022 @default.
• W2031511904 cites W2019755214 @default.
• W2031511904 cites W2021322736 @default.
• W2031511904 cites W2025586198 @default.
• W2031511904 cites W2026438566 @default.
• W2031511904 cites W2027547437 @default.
• W2031511904 cites W2035222611 @default.
• W2031511904 cites W2044113777 @default.
• W2031511904 cites W2044773944 @default.
• W2031511904 cites W2049795022 @default.
• W2031511904 cites W2056976690 @default.
• W2031511904 cites W2061441650 @default.
• W2031511904 cites W2074214791 @default.
• W2031511904 cites W2075700248 @default.
• W2031511904 cites W2076647960 @default.
• W2031511904 cites W2083342497 @default.
• W2031511904 cites W2087691943 @default.
• W2031511904 cites W2089258435 @default.
• W2031511904 cites W2105459496 @default.
• W2031511904 cites W2143044822 @default.
• W2031511904 cites W2156121263 @default.
• W2031511904 cites W2165858836 @default.
• W2031511904 cites W3021250193 @default.
• W2031511904 cites W3188737672 @default.
• W2031511904 cites W4205288846 @default.
• W2031511904 cites W4246169631 @default.
• W2031511904 doi "https://doi.org/10.1080/10641960600946171" @default.
• W2031511904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17060062" @default.
• W2031511904 hasPublicationYear "2006" @default.
• W2031511904 type Work @default.
• W2031511904 sameAs 2031511904 @default.
• W2031511904 citedByCount "7" @default.
• W2031511904 countsByYear W20315119042013 @default.
• W2031511904 countsByYear W20315119042017 @default.
• W2031511904 crossrefType "journal-article" @default.
• W2031511904 hasAuthorship W2031511904A5036062983 @default.
• W2031511904 hasAuthorship W2031511904A5070948074 @default.
• W2031511904 hasAuthorship W2031511904A5091895035 @default.
• W2031511904 hasConcept C112705442 @default.
• W2031511904 hasConcept C126322002 @default.
• W2031511904 hasConcept C134018914 @default.
• W2031511904 hasConcept C142724271 @default.
• W2031511904 hasConcept C197934379 @default.
• W2031511904 hasConcept C204787440 @default.
• W2031511904 hasConcept C27081682 @default.
• W2031511904 hasConcept C2778375690 @default.
• W2031511904 hasConcept C2779766728 @default.
• W2031511904 hasConcept C2779768347 @default.
• W2031511904 hasConcept C555293320 @default.
• W2031511904 hasConcept C71924100 @default.
• W2031511904 hasConcept C84393581 @default.
• W2031511904 hasConcept C87813604 @default.
• W2031511904 hasConcept C98274493 @default.
• W2031511904 hasConceptScore W2031511904C112705442 @default.
• W2031511904 hasConceptScore W2031511904C126322002 @default.
• W2031511904 hasConceptScore W2031511904C134018914 @default.
• W2031511904 hasConceptScore W2031511904C142724271 @default.
• W2031511904 hasConceptScore W2031511904C197934379 @default.
• W2031511904 hasConceptScore W2031511904C204787440 @default.
• W2031511904 hasConceptScore W2031511904C27081682 @default.
• W2031511904 hasConceptScore W2031511904C2778375690 @default.
• W2031511904 hasConceptScore W2031511904C2779766728 @default.
• W2031511904 hasConceptScore W2031511904C2779768347 @default.
• W2031511904 hasConceptScore W2031511904C555293320 @default.
• W2031511904 hasConceptScore W2031511904C71924100 @default.
• W2031511904 hasConceptScore W2031511904C84393581 @default.
• W2031511904 hasConceptScore W2031511904C87813604 @default.
• W2031511904 hasConceptScore W2031511904C98274493 @default.
• W2031511904 hasIssue "7" @default.
• W2031511904 hasLocation W20315119041 @default.
• W2031511904 hasLocation W20315119042 @default.
• W2031511904 hasOpenAccess W2031511904 @default.
• W2031511904 hasPrimaryLocation W20315119041 @default.
• W2031511904 hasRelatedWork W1736016875 @default.
• W2031511904 hasRelatedWork W1993316077 @default.
• W2031511904 hasRelatedWork W1995655843 @default.
• W2031511904 hasRelatedWork W2068108356 @default.
• W2031511904 hasRelatedWork W2137971781 @default.
• W2031511904 hasRelatedWork W2407212191 @default.
• W2031511904 hasRelatedWork W2982235801 @default.
• W2031511904 hasRelatedWork W3207313530 @default.
• W2031511904 hasRelatedWork W4239141576 @default.
• W2031511904 hasRelatedWork W3031236773 @default.
• W2031511904 hasVolume "28" @default.
• W2031511904 isParatext "false" @default.

• next